Old World Vipers—a review about snake venom proteomics of Viperinae and their variations

M Damm, BF Hempel, RD Süssmuth - Toxins, 2021 - mdpi.com
Fine-tuned by millions of years of evolution, snake venoms have frightened but also
fascinated humanity and nowadays they constitute potential resources for drug …

Spider venom: components, modes of action, and novel strategies in transcriptomic and proteomic analyses

N Langenegger, W Nentwig, L Kuhn-Nentwig - Toxins, 2019 - mdpi.com
This review gives an overview on the development of research on spider venoms with a
focus on structure and function of venom components and techniques of analysis. Major …

Snake venomics: fundamentals, recent updates, and a look to the next decade

CH Tan - Toxins, 2022 - mdpi.com
Venomic research, powered by techniques adapted from proteomics, transcriptomics, and
genomics, seeks to unravel the diversity and complexity of venom through which knowledge …

Investigating toxin diversity and abundance in snake venom proteomes

T Tasoulis, TL Pukala, GK Isbister - Frontiers in Pharmacology, 2022 - frontiersin.org
Understanding snake venom proteomes is becoming increasingly important to understand
snake venom biology, evolution and especially clinical effects of venoms and approaches to …

[HTML][HTML] Analytical strategies in venomics

J Slagboom, C Kaal, A Arrahman, FJ Vonk… - Microchemical …, 2022 - Elsevier
Snakebite envenoming is a major issue in certain developing parts of the world, with tens of
thousands of deaths and a multitude of lingering permanent medical conditions on a yearly …

Modern venomics—Current insights, novel methods, and future perspectives in biological and applied animal venom research

BM von Reumont, G Anderluh, A Antunes… - …, 2022 - academic.oup.com
Venoms have evolved> 100 times in all major animal groups, and their components, known
as toxins, have been fine-tuned over millions of years into highly effective biochemical …

Therapeutic potential of peptides derived from animal venoms: current views and emerging drugs for diabetes

A Coulter-Parkhill, S McClean… - Clinical Medicine …, 2021 - journals.sagepub.com
The therapeutic potential of venom-derived drugs is evident today. Currently, several
significant drugs are FDA approved for human use that descend directly from animal venom …

[HTML][HTML] Characterisation of the forest cobra (Naja melanoleuca) venom using a multifaceted mass spectrometric-based approach

CR Wang, AC Harlington, MF Snel… - Biochimica et Biophysica …, 2024 - Elsevier
Snake venoms consist of highly biologically active proteins and peptides that are
responsible for the lethal physiological effects of snakebite envenomation. In order to guide …

Mass spectrometry-based phosphoproteomics in clinical applications

X Wu, YK Liu, AB Iliuk, WA Tao - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Protein phosphorylation is an essential post-translational modification that regulates many
aspects of cellular physiology, and dysregulation of pivotal phosphorylation events is often …

[HTML][HTML] Exploring snake venoms beyond the primary sequence: From proteoforms to protein-protein interactions

CR Wang, LO McFarlane, TL Pukala - Toxicon, 2024 - Elsevier
Snakebite envenomation has been a long-standing global issue that is difficult to treat,
largely owing to the flawed nature of current immunoglobulin-based antivenom therapy and …