Illuminating RNA biology through imaging
RNA processing plays a central role in accurately transmitting genetic information into
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …
Recent advances in plasma-engineered polymers for biomarker-based viral detection and highly multiplexed analysis
Infectious diseases remain a pervasive threat to global and public health, especially in many
countries and rural urban areas. The main causes of such severe diseases are the lack of …
countries and rural urban areas. The main causes of such severe diseases are the lack of …
Mobile platform for rapid sub–picogram-per-milliliter, multiplexed, digital droplet detection of proteins
V Yelleswarapu, JR Buser, M Haber… - Proceedings of the …, 2019 - National Acad Sciences
Digital droplet assays—in which biological samples are compartmentalized into millions of
femtoliter-volume droplets and interrogated individually—have generated enormous …
femtoliter-volume droplets and interrogated individually—have generated enormous …
Subcellular detection of SARS-CoV-2 RNA in human tissue reveals distinct localization in alveolar type 2 pneumocytes and alveolar macrophages
The widespread coronavirus disease 2019 (COVID-19) is caused by infection with the novel
coronavirus SARS-CoV-2. Currently, we have limited understanding of which cells become …
coronavirus SARS-CoV-2. Currently, we have limited understanding of which cells become …
Amplified Fluorescence in Situ Hybridization by Small and Bright Dye-Loaded Polymeric Nanoparticles
S Egloff, N Melnychuk, E Cruz Da Silva, A Reisch… - ACS …, 2021 - ACS Publications
Detection and imaging of RNA at the single-cell level is of utmost importance for
fundamental research and clinical diagnostics. Current techniques of RNA analysis …
fundamental research and clinical diagnostics. Current techniques of RNA analysis …
Sensitive visualization of SARS-CoV-2 RNA with CoronaFISH
The current COVID-19 pandemic is caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). The positive-sense single-stranded RNA virus contains a …
coronavirus 2 (SARS-CoV-2). The positive-sense single-stranded RNA virus contains a …
[HTML][HTML] FISH and chips: a review of microfluidic platforms for FISH analysis
P Rodriguez-Mateos, NF Azevedo, C Almeida… - Medical microbiology …, 2020 - Springer
Fluorescence in situ hybridization (FISH) allows visualization of specific nucleic acid
sequences within an intact cell or a tissue section. It is based on molecular recognition …
sequences within an intact cell or a tissue section. It is based on molecular recognition …
A magnetic micropore chip for rapid (< 1 hour) unbiased circulating tumor cell isolation and in situ RNA analysis
The use of microtechnology for the highly selective isolation and sensitive detection of
circulating tumor cells has shown enormous promise. One challenge for this technology is …
circulating tumor cells has shown enormous promise. One challenge for this technology is …
Catalytic amplification by transition-state molecular switches for direct and sensitive detection of SARS-CoV-2
Despite the importance of nucleic acid testing in managing the COVID-19 pandemic, current
detection approaches remain limited due to their high complexity and extensive processing …
detection approaches remain limited due to their high complexity and extensive processing …
Visualizing adenosine-to-inosine RNA editing in single mammalian cells
Conversion of adenosine to inosine is a frequent type of RNA editing, but important details
about the biology of this conversion remain unknown because of a lack of imaging tools. We …
about the biology of this conversion remain unknown because of a lack of imaging tools. We …