Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …

The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits,
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …

Transcription factors (TFs) orchestrate the gene expression programs that define each cell's
identity. The canonical TF accomplishes this with two domains, one that binds specific DNA …

Human gene expression is regulated by more than 2,000 transcription factors and chromatin
regulators,. Effector domains within these proteins can activate or repress transcription …

Gene regulation plays a critical role in the cellular processes that underlie human health and
disease. The regulatory relationship between transcription factors (TFs), key regulators of …

Transcription factors (TFs) consist of a DNA-binding domain and an activation domain (AD)
that are frequently considered to be independent and exchangeable modules. However …

Eukaryotic transcription factors (TFs) are the final integrators of a complex molecular
feedback mechanism that interfaces with the genome, consolidating information for …

The genomic binding sites of the transcription factor (TF) and tumor suppressor p53 are
unusually diverse with regard to their chromatin features, including histone modifications …

Transcription factors regulate gene expression by binding to regulatory DNA and recruiting
regulatory protein complexes. The DNA-binding and protein-binding functions of …

Despite growing knowledge of the functions of individual human transcriptional effector
domains, much less is understood about how multiple effector domains within the same …