Cirrhosis-associated immune dysfunction

A Albillos, R Martin-Mateos, S Van der Merwe… - Nature Reviews …, 2022 - nature.com
The term cirrhosis-associated immune dysfunction (CAID) comprises the distinctive
spectrum of immune alterations associated with the course of end-stage liver disease …

Acute-on-chronic liver failure clinical guidelines

JS Bajaj, JG O'Leary, JC Lai, F Wong… - Official journal of the …, 2022 - journals.lww.com
In patients with cirrhosis and chronic liver disease, acute-on-chronic liver failure is emerging
as a major cause of mortality. These guidelines indicate the preferred approach to the …

[HTML][HTML] The systemic inflammation hypothesis: towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis

V Arroyo, P Angeli, R Moreau, R Jalan, J Clària… - Journal of …, 2021 - Elsevier
Acute decompensation (AD) of cirrhosis is defined by the development of ascites, hepatic
encephalopathy (HE) and/or variceal bleeding. Ascites is traditionally attributed to …

Hepatorenal syndrome: pathophysiology, diagnosis, and management

DA Simonetto, P Gines, PS Kamath - bmj, 2020 - bmj.com
Hepatorenal syndrome (HRS), the extreme manifestation of renal impairment in patients with
cirrhosis, is characterized by reduction in renal blood flow and glomerular filtration rate …

News in pathophysiology, definition and classification of hepatorenal syndrome: a step beyond the International Club of Ascites (ICA) consensus document

P Angeli, G Garcia-Tsao, MK Nadim, CR Parikh - Journal of hepatology, 2019 - Elsevier
Renal dysfunction is a common, life-threatening complication occurring in patients with liver
disease. Hepatorenal syndrome (HRS) has been defined as a purely “functional” type of …

Guidelines on the management of ascites in cirrhosis

GP Aithal, N Palaniyappan, L China, S Härmälä… - Gut, 2021 - gut.bmj.com
The British Society of Gastroenterology in collaboration with British Association for the Study
of the Liver has prepared this document. The aim of this guideline is to review and …

Acute-on-chronic liver failure

V Arroyo, R Moreau, R Jalan - New England Journal of Medicine, 2020 - Mass Medical Soc
Acute-on-Chronic Liver Failure Acute decompensation in patients with chronic liver disease
is called acute-on-chronic liver failure. Usually, systemic inflammation from infection or an …

Acute-on-chronic liver failure: a distinct clinical syndrome

R Moreau, B Gao, M Papp, R Bañares, PS Kamath - Journal of hepatology, 2021 - Elsevier
There are different operating definitions for acute-on-chronic liver failure (ACLF) in different
geographic regions. Consortia in Western countries have developed definitions that apply to …

[HTML][HTML] Urinary NGAL as a diagnostic and prognostic marker for acute kidney injury in cirrhosis: a prospective study

AS Allegretti, XV Parada, P Endres… - Clinical and …, 2021 - journals.lww.com
METHODS: Urinary NGAL was measured in a prospective cohort of 213 US hospitalized
patients with decompensated cirrhosis (161 with AKI and 52 reference patients without AKI) …

Management of hepatorenal syndrome in liver cirrhosis: a recent update

C Bera, F Wong - Therapeutic advances in gastroenterology, 2022 - journals.sagepub.com
Hepatorenal syndrome (HRS) is a serious form of renal dysfunction in patients with cirrhosis
and ascites. It is an important component of the acute-on-chronic liver failure (ACLF) …