Immunotherapy in treating EGFR-mutant lung cancer: current challenges and new strategies
Lung cancer is the leading cause of cancer-related deaths worldwide. Immune checkpoint
inhibitors, including monoclonal antibodies against programmed death-1 (PD-1) and …
inhibitors, including monoclonal antibodies against programmed death-1 (PD-1) and …
Epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC)
C O'Leary, H Gasper, KB Sahin, M Tang, A Kulasinghe… - Pharmaceuticals, 2020 - mdpi.com
Epidermal growth factor receptor (EGFR) mutations are the most common oncogenic drivers
in non-small-cell lung cancer (NSCLC). Significant developments have taken place which …
in non-small-cell lung cancer (NSCLC). Significant developments have taken place which …
Identification of 5-nitroindazole as a multitargeted inhibitor for CDK and transferase kinase in lung cancer: a multisampling algorithm-based structural study
Lung cancer is the second most common cancer, which is the leading cause of cancer death
worldwide. The FDA has approved almost 100 drugs against lung cancer, but it is still not …
worldwide. The FDA has approved almost 100 drugs against lung cancer, but it is still not …
Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrin α2β1
W Huang, Y Yan, Y Liu, M Lin, J Ma, W Zhang… - Signal transduction and …, 2020 - nature.com
Exosomes play critical roles in regulating various physiological and pathological processes,
including immune stimulation, immune suppression, cardiovascular diseases, and cancers …
including immune stimulation, immune suppression, cardiovascular diseases, and cancers …
KRAS Inhibitor Resistance in MET-Amplified KRASG12C Non–Small Cell Lung Cancer Induced By RAS- and Non–RAS-Mediated Cell Signaling Mechanisms
S Suzuki, K Yonesaka, T Teramura, T Takehara… - Clinical Cancer …, 2021 - AACR
Abstract Purpose: Treatment with KRAS G12C inhibitors such as sotorasib can produce
substantial regression of tumors in some patients with non–small cell lung cancer (NSCLC) …
substantial regression of tumors in some patients with non–small cell lung cancer (NSCLC) …
Towards machine learning-aided lung cancer clinical routines: Approaches and open challenges
Advancements in the development of computer-aided decision (CAD) systems for clinical
routines provide unquestionable benefits in connecting human medical expertise with …
routines provide unquestionable benefits in connecting human medical expertise with …
Cordycepin inhibits drug-resistance non-small cell lung cancer progression by activating AMPK signaling pathway
Lung cancer is the most commonly diagnosed cancer worldwide and it is also the most
leading cause of cancer-related deaths. Although multiple generations of targeted …
leading cause of cancer-related deaths. Although multiple generations of targeted …
Synthesis and anti-cancer activity of ND-646 and its derivatives as acetyl-CoA carboxylase 1 inhibitors
Abstract Acetyl-coA carboxylase 1 (ACC1) is the first and rate-limiting enzyme in the de novo
fatty acid synthesis (FASyn) pathway. In this study, through public database analysis and …
fatty acid synthesis (FASyn) pathway. In this study, through public database analysis and …
[HTML][HTML] A novel mechanism of inhibiting in-stent restenosis with arsenic trioxide drug-eluting stent: Enhancing contractile phenotype of vascular smooth muscle cells …
Objective Arsenic trioxide (ATO or As 2 O 3) has beneficial effects on suppressing neointimal
hyperplasia and restenosis, but the mechanism is still unclear. The goal of this study is to …
hyperplasia and restenosis, but the mechanism is still unclear. The goal of this study is to …
CD44 inhibition attenuates EGFR signaling and enhances cisplatin sensitivity in human EGFR wild‑type non‑small‑cell lung cancer cells
J Yin, H Zhang, X Wu, Y Zhang… - International …, 2020 - spandidos-publications.com
Abstract Cluster of differentiation 44 (CD44) as a transmembrane glycoprotein is found to be
expressed in non‑small cell lung cancer (NSCLC), is significantly associated with NSLC …
expressed in non‑small cell lung cancer (NSCLC), is significantly associated with NSLC …