Controlled assembly and disassembly of multi-protein complexes is central to cellular
signaling. Proteins of the widespread and functionally diverse HORMA family nucleate …

Platinum compounds such as cisplatin, carboplatin and oxaliplatin are widely used in
chemotherapy. Cisplatin induces cytotoxic DNA damage that blocks DNA replication and …

Compelling evidence shows that cancer persister cells represent a major limit to the long-
term efficacy of targeted therapies. However, the phenotype and population dynamics of …

In small cell lung cancer (SCLC), acquired resistance to DNA-damaging therapy is
challenging to study because rebiopsy is rarely performed. We used patient-derived …

Simple Summary REV7 is a multifunctional protein involved in various biological processes
including DNA damage response and mutagenesis, cell cycle regulation, primordial germ …

DNA lesions arising from both exogenous and endogenous sources occur frequently in
DNA. During DNA replication, the presence of unrepaired DNA damage in the template can …

Crosslink repair depends on the Fanconi anemia pathway and translesion synthesis
polymerases that replicate over unhooked crosslinks. Translesion synthesis is regulated via …

Cisplatin is a standard of care for lung cancer, yet platinum therapy rarely results in
substantial tumor regression or a dramatic extension in patient survival. Here, we examined …

Genetic alterations are often acquired during prolonged propagation of pluripotent stem
cells (PSCs). This ruins the stem cell quality and hampers their full applications …

Molecular glues can specifically induce aggregation between two or more proteins to
modulate biological functions. In recent years, molecular glues have been widely used as …