The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

Evidence that psychoactive substance use disorders, bulimia nervosa, pathological
gambling, and sexual addiction share an underlying biopsychological process is …

Animal and human studies indicate that cannabidiol (CBD), a major constituent of cannabis,
has anxiolytic properties. However, no study to date has investigated the effects of this …

The presence and function of CB2 receptors in central nervous system (CNS) neurons are
controversial. We report the expression of CB2 receptor messenger RNA and protein …

Context Cannabis use can both increase and reduce anxiety in humans. The
neurophysiological substrates of these effects are unknown. Objective To investigate the …

Cannabinoid agonists induce complex and often contradictory effects on anxiety in humans
and experimental animals. The data from animal tests provide evidence of dose-dependent …

As far as can be ascertained from archeological sources, preparations of the hemp
Cannabis sativa L. were widely used by humans for either therapeutic or ritual purposes in …

N-Acyl ethanolamines (NAEs) are a large class of signaling lipids implicated in diverse
physiological processes, including nociception, cognition, anxiety, appetite, and …

Background: Preclinical research has suggested that the endocannabinoid system may be
involved in the etiology and/or treatment of depression; however, there are no published …

Observation of actions performed by others activates monkey ventral premotor cortex, where
action meaning, but not object identity, is coded. In a functional MRI (fMRI) study, we …