Owing to their inherent three-dimensionality and structural novelty, spiro scaffolds have
been increasingly utilized in drug discovery. In this brief review, we highlight selected …

The tumour suppressor p53 is the most frequently mutated gene in human cancer, with more
than half of all human tumours carrying mutations in this particular gene. Intense efforts to …

Design of small-molecule inhibitors (MDM2 inhibitors) to block the MDM2–p53 protein–
protein interaction has been pursued as a new cancer therapeutic strategy. In recent years …

Sulfur-containing tetrasubstituted carbon stereocenters are widely present in natural
products, drugs, and biologically active compounds. Catalytic enantioselective construction …

Scaffold modification based on Wang's pioneering MDM2–p53 inhibitors led to novel,
chemically stable spiro-oxindole compounds bearing a spiro [3 H-indole-3, 2′-pyrrolidin]-2 …

The design of multitarget drugs represents a promising strategy in medicinal chemistry and
seems particularly suitable for the discovery of anti-inflammatory drugs. Here, we describe …

Activation of nuclear factor-kappa B (NF-κ B) as a mechanism of host defense against
infection and stress is the central mediator of inflammatory responses. A normal (acute) …

Asymmetric construction of chiral N, S‐acetal skeletons is important because they are widely
present in natural products and pharmaceuticals. Halogen‐bonding is a unique interaction …

As a result of the toxicity of currently available anticancer drugs and the inefficiency of
chemotherapeutic treatments, the design and discovery of effective and selective antitumor …

Asymmetric synthesis of pharmacologically interesting piperidine-fused spiro-oxindole
derivatives has been achieved via an organocatalytic Michael/aza-Henry/hemiaminalization …