Nerve agents are organophosphorus chemical warfare agents that exert their action through
the irreversible inhibition of acetylcholinesterase, with a consequent overstimulation of …

Advances in understanding the regulatory functions of the nervous system have revealed
neural cholinergic signaling as a key regulator of cytokine responses and inflammation …

This review summarizes the efforts of our laboratories to develop a mechanism-based
therapy for the treatment of organophosphate (OP) nerve agent-induced seizures …

The toxic effects of anticholinesterases are due to excessive stimulation of muscarinic and
nicotinic receptors by acetylcholine. Although current treatment for poisoning focusses on …

The Göttingen minipig is fast becoming the standard for assessing dermal chemical hazards
because, like most swine, its skin is predictive of human skin response and because this …

Background Carbamates physostigmine and pyridostigmine have been used as a
pretreatment against poisoning with nerve agents in order to reversibly inhibit and thus …

Earlier reports suggested that galantamine, a drug approved to treat mild-to-moderate
Alzheimer's disease (AD), and other centrally acting reversible acetylcholinesterase (AChE) …

Organophosphorus compounds (OP) pose a significant threat. Administration of human
butyrylcholinesterase (HuBChE) may reduce or prevent OP toxicity. Thus, we evaluated the …

Animal models are essential for evaluating the toxicity of chemical warfare nerve agents
(CWNAs) to extrapolate to human risk and are necessary to evaluate the efficacy of medical …

Chemical agents are classified according to their mechanism of toxicity into categories such
as nerve agents, choking agents, blood agents, blister agents, etc. Among them, nerve …