Nucleic acids are considered as perfect programmable materials for cascade signal
amplification and not merely as genetic information carriers. Among them, catalytic hairpin …

MicroRNAs (miRNAs) are a family of endogenous, small (approximately 22 nucleotides in
length), noncoding, functional RNAs. With the development of molecular biology, the …

The wide extracellular‐intracellular distribution of microRNA requires the on‐site, robust and
efficient activation of catalytic DNA circuits inside live cells. Herein, we develop an efficient …

As a powerful signal amplification tool, the DNA walker has been widely applied to detect
rare microRNA (miRNA) in vivo. Despite the significant advances, a near-infrared (NIR) light …

Nucleic acids, including circulating tumor DNA (ctDNA), microRNA, and virus DNA/RNA,
have been widely applied as potential disease biomarkers for early clinical diagnosis. In this …

Synthetic catalytic DNA circuits have been recognized as a promising signal amplification
toolbox for sensitive intracellular imaging, yet their selectivity and efficiency are always …

Sensitive and accurate analysis of low‐concentration of tumor‐derived exosomes (Exos) in
biofluids is essential for noninvasive cancer diagnosis but is still challenging due to the lack …

DNAzymes have been recognized as promising transducing agents for visualizing
endogenous biomarkers, but their inefficient intracellular delivery and limited amplification …

Photoresponsive nucleic acids attract growing interest as functional constituents in materials
science. Integration of photoisomerizable units into DNA strands provides an ideal handle …

DNA-based probes constitute a versatile platform for making biological measurements due
to their ability to recognize both nucleic acid and non-nucleic acid targets, ease of synthesis …