Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult
haematopoietic system. Understanding how early haematopoietic development occurs is of …

Howard Hughes Medical Institute Memorial Sloan-Kettering Cancer Center process are now
understood. Adjacent to the kinase domain of the type I receptors is a conserved 30 amino …

Cell proliferation, differentiation and death are controlled by a multitude of cell? cell signals,
and loss of this control has devastating consequences. Prominent among these regulatory …

The transforming growth factor ß (TGF-ß) family of hormonally active polypeptides have
attracted much attention because of their ability to control cellular functions that underwrite …

The discovery of mouse embryonic stem (ES) cells> 20 years ago represented a major
advance in biology and experimental medicine, as it enabled the routine manipulation of the …

The second edition of The Lateralized Brain provides for readers a volume detailing the
functional and structural differences between the left and right hemispheres of the brain …

▪ Abstract Myostatin is a secreted protein that acts as a negative regulator of skeletal muscle
mass. During embryogenesis, myostatin is expressed by cells in the myotome and in …

The cellular and molecular events regulating the induction and tissue-specific differentiation
of endoderm are central to our understanding of the development and function of many …

▪ Abstract Researchers have long predicted that complex carbohydrates on cell surfaces
would play important roles in developmental processes because of the observation that …

Embryonic stem cells (ESCs) form descendants of all three germ layers when differentiated
as aggregates, termed embryoid bodies. In vivo, differentiation of cells depends on signals …