Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies

JA Batsis, DT Villareal - Nature Reviews Endocrinology, 2018 - nature.com
The prevalence of obesity in combination with sarcopenia (the age-related loss of muscle
mass and strength or physical function) is increasing in adults aged 65 years and older. A …

[HTML][HTML] The relationship between circulating testosterone and inflammatory cytokines in men

NV Mohamad, SK Wong, WNW Hasan, JJ Jolly… - The Aging …, 2019 - Taylor & Francis
Testosterone is the predominant gonadal androgen in men. Low testosterone levels are
found to be associated with an increased in metabolic risk and systematic inflammation …

The anti-inflammatory effects of testosterone

VE Bianchi - Journal of the endocrine society, 2019 - academic.oup.com
Low plasma testosterone (T) levels correlated with metabolic syndrome, cardiovascular
diseases, and increased mortality risk. T exerts a significant effect on the regulation of …

Why does COVID‐19 kill more elderly men than women? Is there a role for testosterone?

V Papadopoulos, L Li, M Samplaski - Andrology, 2021 - Wiley Online Library
Background Recent epidemiological data indicate that there may be a gender predisposition
to COVID‐19, with men predisposed to being most severely affected, and older men …

Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double …

SY Kalinchenko, YA Tishova… - Clinical …, 2010 - Wiley Online Library
Objective Men with the metabolic syndrome (MetS) have low plasma testosterone (T) levels.
The aim of this study was to establish whether the normalization of plasma T improves the …

[HTML][HTML] Testosterone: a vascular hormone in health and disease

DM Kelly, TH Jones - Journal of Endocrinology, 2013 - joe.bioscientifica.com
Coronary heart disease is a leading cause of premature death in men. Epidemiological
studies have shown a high prevalence of low serum testosterone levels in men with …

Testosterone deficiency, insulin resistance and the metabolic syndrome

M Zitzmann - Nature Reviews Endocrinology, 2009 - nature.com
Changing lifestyles and an excess of food supply in developed countries have resulted in an
increasing prevalence of overweight and obesity. As a consequence, a disorder of complex …

[HTML][HTML] Do androgens modulate the pathophysiological pathways of inflammation? Appraising the contemporary evidence

A Traish, J Bolanos, S Nair, F Saad… - Journal of clinical …, 2018 - mdpi.com
The role of testosterone in the pathophysiology of inflammation is of critical clinical
importance; however, no universal mechanism (s) has been advanced to explain the …

[HTML][HTML] Influence of androgens on immunity to self and foreign: effects on immunity and cancer

I Ben-Batalla, ME Vargas-Delgado… - Frontiers in …, 2020 - frontiersin.org
It is well-known that sex hormones can directly and indirectly influence immune cell function.
Different studies support a suppressive role of androgens on different components of the …

Testosterone deficiency: a risk factor for cardiovascular disease?

TH Jones - Trends in Endocrinology & Metabolism, 2010 - cell.com
Male gender is a major risk factor for premature cardiovascular death, a relationship not yet
explained. Low testosterone in men is a risk factor for the metabolic syndrome and type 2 …