SPARC is a multifunctional glycoprotein that belongs to the matricellular group of proteins. It
modulates cellular interaction with the extracellular matrix (ECM) by its binding to structural …

Structure of SPARC protein. A ribbon diagram derived from crystallographic data shows the
three modular domains of SPARC. Representative activities attributed to each domain are …

Despite the existence of tumor-specific immune cells, most tumors have devised strategies
to avoid immune attack. We demonstrate here that galectin-1 (Gal-1), a negative regulator of …

Disruption of the endothelial barrier by tumour-derived secreted factors is a critical step in
cancer cell extravasation and metastasis. Here, by comparative proteomic analysis of …

SPARC (secreted protein, acidic and rich in cysteine) is a unique matricellular glycoprotein
that is expressed by many different types of cells and is associated with development …

During progression of melanoma, malignant melanocytes can be reprogrammed into
mesenchymal-like cells through a process similar to epithelial-mesenchymal transition …

The late stages of human breast cancer development are poorly understood complex
processes associated with the expression of genes by cancers that promote specific …

The family of matricellular proteins comprises molecules with disparate biology. The main
characteristic of matricellular proteins is to be expressed during tissue renewal and repair in …

Tumor growth is essentially the result of an evolving cross-talk between malignant and
surrounding stromal cells (fibroblasts, endothelial cells and inflammatory cells). This …

The ability to effectively target a tumor to achieve complete regression and cure is the
ultimate goal that drives our need to better understand tumor biology. Recently, SPARC has …