Cocrystals and drug–drug cocrystals of anticancer drugs: A perception towards screening techniques, preparation, and enhancement of drug properties
DD Kara, M Rathnanand - Crystals, 2022 - mdpi.com
The most favored approach for drug administration is the oral route. Several anticancer
drugs come under this category and mostly lack solubility and oral bioavailability, which are …
drugs come under this category and mostly lack solubility and oral bioavailability, which are …
Sildenafil 4.0—Integrated synthetic chemistry, formulation and analytical strategies effecting immense therapeutic and societal impact in the fourth industrial era
A Ouranidis, A Tsiaxerli, E Vardaka, CK Markopoulou… - Pharmaceuticals, 2021 - mdpi.com
Sildenafil is a potent selective, reversible inhibitor of phosphodiesterase type 5 (PDE5)
approved for the treatment of erectile dysfunction and pulmonary arterial hypertension …
approved for the treatment of erectile dysfunction and pulmonary arterial hypertension …
Synthesis and characterization of a new norfloxacin/resorcinol cocrystal with enhanced solubility and dissolution profile
A new cocrystal of Norfloxacin, a poorly soluble fluoroquinolone antibiotic, has been
synthetized by a solvent-mediated transformation experiment in toluene, using resorcinol as …
synthetized by a solvent-mediated transformation experiment in toluene, using resorcinol as …
[HTML][HTML] Theoretical calculation of the adiabatic electron affinities of the monosubstituted benzaldehyde derivatives
In the current study, several computational models were examined to calculate accurate
adiabatic electron affinity (AEA) of twelve m-and p-monosubstituted benzaldehyde …
adiabatic electron affinity (AEA) of twelve m-and p-monosubstituted benzaldehyde …
Expanding the solid-state landscape of dexamethasone: a specific sandwich structure in facilitating the formation of kinetically stable cocrystals from …
Dexamethasone (DEX), a widely prescribed anti-inflammatory drug, displays limited crystal
forms. Cocrystallization constitutes an untapped strategy for expanding its solid-state …
forms. Cocrystallization constitutes an untapped strategy for expanding its solid-state …
Evaluation of synthon influence on ethenzamide–polyphenol pharmaceutical cocrystals
FJ Acebedo-Martínez, A Domínguez-Martín… - …, 2023 - pubs.rsc.org
The pharmaceutical cocrystal landscape of ethenzamide has been addressed during the
past years with the aim of improving its physicochemical properties, mainly solubility and …
past years with the aim of improving its physicochemical properties, mainly solubility and …
[HTML][HTML] The solid state landscape of the sildenafil drug
Sildenafil, the active ingredient of the drug developed by Pfizer for the treatment of erectile
dysfunction was firstly synthesized in 1989 in the United Kingdom and since then it has …
dysfunction was firstly synthesized in 1989 in the United Kingdom and since then it has …
Weak interactions in cocrystals of isoniazid with glycolic and mandelic acids
R Álvarez-Vidaurre, A Castiñeiras, A Frontera… - Crystals, 2021 - mdpi.com
This work deals with the preparation of pyridine-3-carbohydrazide (isoniazid, inh) cocrystals
with two α-hydroxycarboxylic acids. The interaction of glycolic acid (H2ga) or d, l-mandelic …
with two α-hydroxycarboxylic acids. The interaction of glycolic acid (H2ga) or d, l-mandelic …
Substitution effect on the adiabatic ionization potential, vertical ionization potential, electrophilicity, and nucleophilicity of some hydantoin drug derivatives …
In the current paper, the adiabatic ionization potentials (AIP) for 29 hydantoin derivatives
and hydantoin‐based drugs such as allantoin, phenytoin, mephenytoin, nilutamide …
and hydantoin‐based drugs such as allantoin, phenytoin, mephenytoin, nilutamide …
The role of hydrogen bonding in the conformational stability of 2-methoxyresorcinol: Insights from theoretical calculations, SERS spectroscopy, and solvent effect
NA Fathurrahman, MA Alhaboudal… - Journal of Molecular …, 2024 - Elsevier
Resorcinol derivatives exhibit unique structural and electronic features. The presence of two
hydroxyl groups, along with other substituents, can greatly impact these molecules' …
hydroxyl groups, along with other substituents, can greatly impact these molecules' …