Endotypes and phenotypes in obstructive sleep apnea

A Malhotra, O Mesarwi, JL Pepin… - Current opinion in …, 2020 - journals.lww.com
OSA is a heterogeneous disease with highly varying underlying mechanisms. OSA has
variable clinical manifestations with definable subsets having risk of particular …

More than the sum of the respiratory events: personalized medicine approaches for obstructive sleep apnea

BA Edwards, S Redline, SA Sands… - American journal of …, 2019 - atsjournals.org
Traditionally, the presence and severity of obstructive sleep apnea (OSA) have been defined
by the apnea–hypopnea index (AHI). Continuous positive airway pressure is generally first …

Acetazolamide for OSA and central sleep apnea: a comprehensive systematic review and meta-analysis

CN Schmickl, SA Landry, JE Orr, K Chin, K Murase… - Chest, 2020 - Elsevier
Background Therapy options for OSA and central sleep apnea (CSA) are limited, thus many
patients remain untreated. Clinically, acetazolamide is sometimes used for CSA; however …

Novel avenues to approach non-CPAP therapy and implement comprehensive obstructive sleep apnoea care

JL Pépin, P Eastwood, DJ Eckert - European Respiratory …, 2022 - Eur Respiratory Soc
Recent advances in obstructive sleep apnoea (OSA) pathophysiology and translational
research have opened new lines of investigation for OSA treatment and management. Key …

Daily exposure to mild intermittent hypoxia reduces blood pressure in male patients with obstructive sleep apnea and hypertension

GS Panza, S Puri, HS Lin, MS Badr… - American Journal of …, 2022 - atsjournals.org
Rationale: Daily exposure to mild intermittent hypoxia (MIH) may elicit beneficial
cardiovascular outcomes. Objectives: To determine the effect of 15 days of MIH and in-home …

Neural circuitry underlying waking up to hypercapnia

S Kaur, CB Saper - Frontiers in neuroscience, 2019 - frontiersin.org
Obstructive sleep apnea is a sleep and breathing disorder, in which, patients suffer from
cycles of atonia of airway dilator muscles during sleep, resulting in airway collapse, followed …

Prevalence, characteristics, and respiratory arousal threshold of positional obstructive sleep apnea in China: a large scale study from Shanghai Sleep Health Study …

W Huang, X Wang, C Xu, H Xu, H Zhu, S Liu, J Zou… - Respiratory …, 2022 - Springer
Purpose To evaluate the prevalence, characteristics, and respiratory arousal threshold
(ArTH) of Chinese patients with positional obstructive sleep apnea (POSA) according to the …

Sleep medicine: Practice, challenges and new frontiers

L Parrino, P Halasz, A Szucs, RJ Thomas… - Frontiers in …, 2022 - frontiersin.org
Sleep medicine is an ambitious cross-disciplinary challenge, requiring the mutual
integration between complementary specialists in order to build a solid framework. Although …

Low arousal threshold: a common pathophysiological trait in patients with obstructive sleep apnea syndrome and asthma

C Antonaglia, G Passuti, F Giudici, F Salton, B Ruaro… - Sleep and …, 2023 - Springer
Introduction Obstructive sleep apnea syndrome (OSAS) and asthma are two diseases with a
high epidemiological impact that may often coexist. Both diseases have underlying …

Physiological traits and adherence to sleep apnea therapy in individuals with coronary artery disease

AV Zinchuk, J Chu, J Liang, Y Celik… - American Journal of …, 2021 - atsjournals.org
Rationale: Untreated obstructive sleep apnea (OSA) is associated with adverse outcomes in
patients with coronary artery disease (CAD). Continuous positive airway pressure (CPAP) is …