Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Cytochrome c (Cytc) is essential in mitochondrial electron transport and intrinsic type II
apoptosis. Mammalian Cytc also scavenges reactive oxygen species (ROS) under healthy …

The exploration of effective spinal cord injury (SCI) healing still remain a great challenge
due to the high morbidity, complex pathology and unclear targets. Human umbilical cord …

Genetically engineered mice are used extensively to examine molecular responses to spinal
cord injury (SCI). Inherent strain differences may confound behavioral outcomes; therefore …

Proteases or proteolytic enzymes form one of the largest and more important groups of
enzymes. Proteases selectively catalyze the hydrolysis of peptide bonds and can be divided …

Chronic inflammation is a pathologic feature of neurodegeneration and aging; however, the
mechanism regulating this process is not understood. Melatonin, an endogenous free …

Spinal cord injury (SCI) is a devastating and common neurologic disorder that has profound
influences on modern society from physical, psychosocial, and socioeconomic perspectives …

A form of cell death called apoptosis is a prominent feature in a broad spectrum of
neurodegenerative diseases, ranging from stroke to Huntington's disease. Hypoxia, toxic …

Tetracyclines are broad-spectrum antibiotics that act as such at the ribosomal level where
they interfere with protein synthesis. They were first widely prescribed by dermatologists in …

Acute neurological conditions such as cerebrovascular diseases and trauma are associated
with irreversible loss of neurons and glial cells. Severe or prolonged injury results in …