The bone marrow is an important dose-limiting cell renewal tissue for chemotherapy, wide-
field irradiation, and autologous bone marrow transplantion. Over the past 5–10 years a …

Cell divisions during embryonic development give rise to new differentiated cell types or
increase the total number of cells in the embryo. In contrast, the major role of cell division in …

The β-thymosins are a family of highly conserved polar 5 kDa peptides originally thought to
be thymic hormones. About 10 years ago, thymosin β4 as well as other members of this …

The most classical view of the renin-angiotensin system (RAS) emphasizes its role as an
endocrine regulator of sodium balance and blood pressure. However, it has long become …

Angiotensin I-converting enzyme (ACE) has two homologous active NH2-and COOH-
terminal domains and displays activity toward a broad range of substrates. The tetrapeptide …

Angiotensin I-converting enzyme (ACE) is a zinc-dipeptidyl carboxypeptidase, which
contains two similar domains, each possessing a functional active site. Respective …

The goal of this review is to highlight recent advances in our understanding of the
pathobiology of leukemias and lymphomas. Our theme throughout will be to relate specific …

THE nuclear factor GF-1 (also known as NF-E1, Eryf-1; refs 1–3 respectively) is important in
regulation of the transcription of globin and other genes4 that are specifically expressed in …

THE haemopoietic system has three main compartments: multi-potential stem cells,
intermediate stage progenitor cells and mature cells. The availability of simple reproducible …

We have used antisense oligonucleotides to study the roles of transforming growth factor
beta (TGF-beta) and the two antioncogenes, retinoblastoma susceptibility (Rb) and p53, in …