Endothelial cells (ECs) constitute the innermost layer in all blood vessels to maintain the
structural integrity and microcirculation function for coronary microvasculature. Impaired …

The molecular mechanisms underlying atrial fibrillation (AF), the most common form of
arrhythmia, are poorly understood and therefore target-specific treatment options remain an …

Significance: Mitochondrial (mt) reticulum network in the cell possesses amazing
ultramorphology of parallel lamellar cristae, formed by the invaginated inner mitochondrial …

Abnormal glucose metabolism is central to neurodegeneration, and considerable evidence
suggests that abnormalities in key enzymes of the tricarboxylic acid (TCA) cycle underlie the …

Reactive oxygen species (ROS; free radical form O2•−, superoxide radical; OH•, hydroxyl
radical; ROO•, peroxyl; RO•, alkoxyl and non‐radical form 1O2, singlet oxygen; H2O2 …

Mitochondria use hydrogen peroxide (H 2 O 2) as a mitokine for cell communication. H 2 O 2
output for signaling depends on its rate of production and degradation, both of which are …

Pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) are vital entry
points for monosaccharides and amino acids into the Krebs cycle and thus integral for …

Background: It has been four decades since protein S-glutathionylation was proposed to
serve as a regulator of cell metabolism. Since then, this redox-sensitive covalent …

Mitochondrial reactive oxygen species (mROS) are routinely produced at several sites within
the organelle. The balance in their formation and elimination is maintained by a complex …

Heart failure is a growing health burden worldwide characterized by alterations in excitation-
contraction coupling, cardiac energetic deficit and oxidative stress. While current treatments …