Cancer progression often benefits from the selective conditions present in the tumour
microenvironment, such as the presence of cancer-associated fibroblasts (CAFs) …

During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …

Efficient delivery of chemotherapeutic drugs to tumor cells is one of the crucial issues for
modern day cancer therapy. In this article, we report the synthesis of poly ethylene glycol …

HIFs have long been associated with resistance to therapy, metastasis, and poor survival
rates in cancer patients. In parallel, although the tumor-suppressor p53 acts as the first …

The development of new strategies of anticancer immunotherapies has provided promising
approaches in the treatment of solid tumors. However, despite the improved survival in …

Ageing leads to a progressive deterioration of structure and function of all organs over the
time. During this process endothelial cells undergo senescence and manifest significant …

The development of simple, cost-effective, and advanced multifunctional technology is the
need of the hour to combat cancer as well as bacterial infections. There have been reports of …

Transition from pluripotency to differentiation is a pivotal yet poorly understood
developmental step. Here, we show that the tumour suppressor RASSF1A is a key player …

Metastatic melanoma is one of the most aggressive tumors, with frequent mutations affecting
components of the MAPK pathway, mainly protein kinase BRAF. Despite promising initial …

Significance: The p53 family of transcription factors, including p53, p63, and p73, plays key
roles in both biological and pathological processes, including cancer and neural …