Roles and mechanisms of alternative splicing in cancer—implications for care
SC Bonnal, I López-Oreja, J Valcárcel - Nature reviews Clinical …, 2020 - nature.com
Removal of introns from messenger RNA precursors (pre-mRNA splicing) is an essential
step for the expression of most eukaryotic genes. Alternative splicing enables the regulated …
step for the expression of most eukaryotic genes. Alternative splicing enables the regulated …
Mechanisms of enzalutamide resistance in castration‐resistant prostate cancer and therapeutic strategies to overcome it
Y Wang, J Chen, Z Wu, W Ding, S Gao… - British journal of …, 2021 - Wiley Online Library
Prostate cancer is the second most common malignancy in men and androgen deprivation
therapy is the first‐line therapy. However, most cases will eventually develop castration …
therapy is the first‐line therapy. However, most cases will eventually develop castration …
Phase separation drives aberrant chromatin looping and cancer development
The development of cancer is intimately associated with genetic abnormalities that target
proteins with intrinsically disordered regions (IDRs). In human haematological malignancies …
proteins with intrinsically disordered regions (IDRs). In human haematological malignancies …
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis
Canonically, EZH2 serves as the catalytic subunit of PRC2, which mediates H3K27me3
deposition and transcriptional repression. Here, we report that in acute leukaemias, EZH2 …
deposition and transcriptional repression. Here, we report that in acute leukaemias, EZH2 …
Targeting the p300/CBP axis in lethal prostate cancer
J Welti, A Sharp, N Brooks, W Yuan, C McNair… - Cancer Discovery, 2021 - AACR
Resistance to androgen receptor (AR) blockade in castration-resistant prostate cancer
(CRPC) is associated with sustained AR signaling, including through alternative splicing of …
(CRPC) is associated with sustained AR signaling, including through alternative splicing of …
A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models
Interactions between WD40 repeat domain protein 5 (WDR5) and its various partners such
as mixed lineage leukemia (MLL) and c-MYC are essential for sustaining oncogenesis in …
as mixed lineage leukemia (MLL) and c-MYC are essential for sustaining oncogenesis in …
Cellular and molecular mechanisms underlying prostate cancer development: therapeutic implications
U Testa, G Castelli, E Pelosi - Medicines, 2019 - mdpi.com
Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …
Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
Abstract WD repeat domain 5 (WDR5), an integral component of the MLL/KMT2A lysine
methyltransferase complex, is critically involved in oncogenesis and represents an attractive …
methyltransferase complex, is critically involved in oncogenesis and represents an attractive …
BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis
Trimethylated histone H3 lysine 27 (H3K27me3) regulates gene repression, cell-fate
determination and differentiation. We report that a conserved bromo-adjacent homology …
determination and differentiation. We report that a conserved bromo-adjacent homology …
A cryptic transactivation domain of EZH2 binds AR and AR's splice variant, promoting oncogene activation and tumorous transformation
Abstract Enhancer of Zeste Homolog 2 (EZH2) and androgen receptor (AR) are crucial
chromatin/gene regulators involved in the development and/or progression of prostate …
chromatin/gene regulators involved in the development and/or progression of prostate …