Stem cells play an important role in restoring cardiac function in the damaged heart. In order
to mediate repair, stem cells need to replace injured tissue by differentiating into specialized …

Extracellular vesicles (EVs) are nanosized vesicles with a lipid bilayer that are released from
cells of the cardiovascular system, and are considered important mediators of intercellular …

Rationale: MicroRNAs (miRNAs) have been implicated in the epigenetic regulation of key
metabolic, inflammatory, and antiangiogenic pathways in type 2 diabetes (DM) and may …

Endothelial dysfunction, the shift from a healthy endothelium to a damaged pro-coagulative,
pro-inflammatory, and pro-vasoconstrictive phenotype, is an early event in many chronic …

Bone-marrow-derived EPCs (endothelial progenitor cells) play an integral role in the
regulation and protection of the endothelium, as well as new vessel formation. Peripheral …

Recent findings demonstrated the importance of microRNAs (miRNAs) in the vasculature
and the orchestration of lipid metabolism and glucose homeostasis. MiRNA networks …

Small-diameter vascular grafts (SDVGs) are urgently required for clinical applications.
Constructing vascular grafts mimicking the defining features of native arteries is a promising …

The concept of endothelial progenitor cells (EPCs) has attracted considerable interest in
cardiovascular research, but despite a decade of research there are still no specific markers …

Background Current evidence suggests that endothelial progenitor cells (EPC) contribute to
ischemic tissue repair by both secretion of paracrine factors and incorporation into …

Within a mammalian organism, the interaction among cells both at short and long distances
is mediated by soluble factors released by cells into the extracellular environment. The …