Signal flow in the NMDA receptor–dependent phosphoproteome regulates postsynaptic plasticity for aversive learning

Y Funahashi, RU Ahammad, X Zhang, E Hossen… - Science …, 2024 - science.org
Structural plasticity of dendritic spines in the nucleus accumbens (NAc) is crucial for learning
from aversive experiences. Activation of NMDA receptors (NMDARs) stimulates Ca2+ …

Reduced Neurite Arborization in Primary Dopaminergic Neurons in Autism-Like Shank3B-Deficient Mice

Z Bacova, T Havranek, D Mihalj, V Borbelyova… - Molecular …, 2024 - Springer
Despite many studies on dopamine changes in autism, specific alterations in midbrain
dopamine neurons projecting to the striatum and cortex remain unclear. Mouse models with …

Exosomes can modulate the early hyperexcitability in cortical neurons with ASD-associated Shank3 mutation.

A Choudhary, I Rosh, Y Hussein, A Shemen, WA Rike… - bioRxiv, 2024 - biorxiv.org
Shank3, a scaffolding protein, is critical for synaptic structure and function, particularly for the
formation and maintenance of dendritic spines. Shank3 mutations are strongly implicated in …

[引用][C] Efectos de la microbiota intestinal sobre la neuroquímica de los trastornos del espectro autista

M Matamoros Ruiz - 2023