This paper is the third in a series of reviews published in this issue resulting from the
University of California Davis Cardiovascular Symposium 2014: Systems approach to …

NCX proteins explore the electrochemical gradient of Na+ to mediate Ca 2+-fluxes in
exchange with Na+ either in the Ca 2+-efflux (forward) or Ca 2+-influx (reverse) mode …

Background and Purpose Early identification of drug‐induced cardiac adverse events is key
in drug development. Human‐based computer models are emerging as an effective …

Ischemic heart diseases (IHD) are the leading cause of death worldwide. Although the
principal form of treatment of IHD is myocardial reperfusion, the recovery of coronary blood …

Background: Long QT syndromes (LQTS) arise from many genetic and nongenetic causes
with certain characteristic ECG features preceding polymorphic ventricular tachyarrhythmias …

Aims Heart failure with preserved ejection fraction (HFpEF) is increasingly common, but the
underlying cellular mechanisms are not well understood. We investigated cardiomyocyte …

Increased sodium influx via incomplete inactivation of the major cardiac sodium channel
NaV1. 5 is correlated with an increased incidence of atrial fibrillation (AF) in humans. Here …

A rapid growth in the incidence of diabetes and obesity has transpired to a major heath
issue and economic burden in the postindustrial world, with more than 29 million patients …

Cell membrane deformation is an important feature that occurs during many physiological
processes, and its study has been put to good use to investigate cardiomyocyte function …

Buprenorphine is a μ-opioid receptor (MOR) partial agonist used to manage pain and
addiction. QTC prolongation that crosses the 10 msec threshold of regulatory concern was …