Molecular hybridization is a well-exploited medicinal chemistry strategy that aims to combine
two molecules (or parts of them) in a new, single chemical entity. Recently, it has been …

Alzheimer's disease, a major and increasing global health challenge, is an irreversible,
progressive form of dementia, associated with an ongoing decline of brain functioning. The …

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders in elderly
people. Considering the multifactorial nature of AD, the concept of multi-target-directed …

Redox impairment is a prominent feature of Alzheimer's disease (AD). It has led to the
“oxidative stress hypothesis”, which proposes antioxidants as beneficial therapeutic tools in …

We report the identification of multitarget anti-Alzheimer compounds designed by combining
a naphthoquinone function and a tacrine fragment. In vitro, 15 compounds displayed …

To date, the pharmacotherapy of Alzheimer's disease (AD) has relied on
acetylcholinesterase (AChE) inhibitors (AChEIs) and, more recently, an N-methyl-D …

Coupling of two distinct pharmacophores, tacrine and trolox, endowed with different
biological properties, afforded 21 hybrid compounds as novel multifunctional candidates …

To discover novel BChE inhibitors, a hierarchical virtual screening protocol followed by
biochemical evaluation was applied. The most potent compound 8012-9656 (eq BChE …

In this work, we describe the synthesis and in vitro evaluation of a novel series of multitarget-
directed ligands (MTDL) displaying both nanomolar dual-binding site (DBS) …

Progressive cognitive decline in Alzheimer's disease (AD) is a growing challenge. Present
therapies are based on acetylcholinesterase inhibition providing only temporary relief …