The field of nanotechnology has revolutionised global attempts to prevent, treat, and
eradicate infectious diseases in the foreseen future. Nanovaccines have proven to be a …

Humanity is currently facing the challenge of two devastating pandemics caused by two very
different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which …

Background Long-acting injectable regimens may simplify therapy for patients with human
immunodeficiency virus type 1 (HIV-1) infection. Methods We conducted a phase 3 …

We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred
nine individuals with this variant had a 0.54 to 0.74 log10 increase (ie, a~ 3.5-fold to 5.5-fold …

In topological data analysis (TDA), one often studies the shape of data by constructing a
filtered topological space, whose structure is then examined using persistent homology …

Background Global HIV-1 genetic diversity and evolution form a major challenge to
treatment and prevention efforts. An increasing number of distinct HIV-1 recombinants have …

Global SARS-CoV-2 genomic surveillance efforts have provided critical data on the ongoing
evolution of the virus to inform best practices in clinical care and public health throughout the …

Human immunodeficiency virus type 1 (HIV-1) subtype C (C-HIV) is the most prevalent form
of HIV-1 globally, accounting for approximately 50% of infections worldwide. C-HIV is the …

Dendritic cells (DCs) are a type of innate immune cells with major relevance in the
establishment of an adaptive response, as they are responsible for the activation of …

Background HIV poses significant challenges for vaccine development due to its high
genetic mutation and recombination rates. Understanding the distribution of HIV subtypes …