Stroke is a main cause of mortality and morbidity worldwide. Despite the increasing
development of innovative treatments for stroke, most are unsuccessful in clinical trials. In …

Stroke remains a major cause of death and disability in the United States and around the
world. Solid safety and efficacy profiles of novel stroke therapeutics have been generated in …

Objective Pressure overload can result in significant changes to the structure of blood
vessels, a process known as vascular remodeling. High levels of tension can cause vascular …

Intimal hyperplasia is one of the major complications after stenting, but the underlying
mechanisms remain unclear. Our previous study found that the dipeptidyl peptidase IV (DPP …

Abstract Background Nitric oxide (• NO) is more effective at inhibiting neointimal hyperplasia
following arterial injury in male versus female rodents, though the etiology is unclear. Given …

Enhanced mitochondrial respiration in vascular smooth muscle cells (VSMCs) is involved in
neointima formation in response to vascular injury. In the present study, we investigated the …

Dietary Nrf2 activators increase expression of phase 2 protein genes in cells undergoing
oxidative stress resulting in a lowering of oxidative stress. Oxidative stress promotes …

Aims Angiogenesis is defined as the sprouting of capillaries from pre-existing vasculature. It
is a complex process that includes endothelial proliferation, migration, and tube formation …

Background and aims New treatments are needed to prevent neointimal hyperplasia that
contributes to post-angioplasty and stent restenosis in patients with coronary artery disease …

Although cholecystokinin octapeptide-8 is important for neurological function, its
neuroprotective properties remain unclear. We speculated that cholecystokinin octapeptide …