Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels
largely expressed in the nervous system of rodents and humans. At least six isoforms …

Acid-sensing ion channel 1a (ASIC1a) is a member of the extracellular H+-activated cation
channel family. Emerging evidence has suggested that ASIC1a plays a crucial role in the …

Acid-sensing ion channels (ASICs) have emerged as important, albeit challenging
therapeutic targets for pain, stroke, etc. One approach to developing therapeutic agents …

Rationale: Synovial inflammation is one of the main pathological features of rheumatoid
arthritis (RA) and is a key factor leading to the progression of RA. Understanding the …

Abstract Cytokines, particularly IL-6, play a crucial role in modulating immune responses in
the central nervous system (CNS). Elevated IL-6 levels have been observed in …

Background and Purpose: Brain acidosis is prevalent in stroke and other neurological
diseases. Acidosis can have paradoxical injurious and protective effects. The purpose of this …

Simple Summary Human neuroblastoma SH-SY5Y is used in neurobiology for studying
various neuropathophysiological processes. In this study, we differentiated neuroblastoma …

Oxidative stress is intimately tied to neurodegenerative diseases, including Parkinson's
disease and amyotrophic lateral sclerosis, and acute injuries, such as ischemic stroke and …

Brain acid signaling plays important roles in both physiological and disease conditions. One
key neuronal metabotropic proton receptor in the brain is GPR68, which contributes to …

Background: Early life adversities are risk factors for anxiety disorders and for pain
syndromes, which are, in turn, highly comorbid with anxiety disorders. Repeated cross …