[HTML][HTML] Role of the CXCL8-CXCR1/2 axis in cancer and inflammatory diseases
H Ha, B Debnath, N Neamati - Theranostics, 2017 - ncbi.nlm.nih.gov
The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …
Electrochemical methods for the analysis of clinically relevant biomolecules
Rapid progress in identifying biomarkers that are hallmarks of disease has increased
demand for high-performance detection technologies. Implementation of electrochemical …
demand for high-performance detection technologies. Implementation of electrochemical …
Neutrophil extracellular traps in cancer
L Cristinziano, L Modestino, A Antonelli… - Seminars in cancer …, 2022 - Elsevier
Beyond their well-known functions in the acute phases of the immune response, neutrophils
play important roles in the various phases of tumor initiation and progression, through the …
play important roles in the various phases of tumor initiation and progression, through the …
[HTML][HTML] Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases
The chemokine receptor CXCR2 and its ligands are implicated in the progression of tumours
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …
Interleukin-8 in cancer pathogenesis, treatment and follow-up
C Alfaro, MF Sanmamed, ME Rodríguez-Ruiz… - Cancer treatment …, 2017 - Elsevier
Abstract Interleukin-8 (CXCL8) was originally described as a chemokine whose main
function is the attraction of a polymorphonuclear inflammatory leukocyte infiltrate acting on …
function is the attraction of a polymorphonuclear inflammatory leukocyte infiltrate acting on …
The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases
Chemokines are small proteins that control several tissue functions, including cell
recruitment and activation under homeostatic and inflammatory conditions. CXCL8 …
recruitment and activation under homeostatic and inflammatory conditions. CXCL8 …
The IL-8/IL-8R axis: a double agent in tumor immune resistance
JM David, C Dominguez, DH Hamilton, C Palena - Vaccines, 2016 - mdpi.com
Interleukin-8 (IL-8, CXCL8) is a pro-inflammatory chemokine produced by various cell types
to recruit leukocytes to sites of infection or tissue injury. Acquisition of IL-8 and/or its …
to recruit leukocytes to sites of infection or tissue injury. Acquisition of IL-8 and/or its …
Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid tumors
M Bilusic, CR Heery, JM Collins, RN Donahue… - … for immunotherapy of …, 2019 - Springer
Background HuMax-IL8 (now known as BMS-986253) is a novel, fully human monoclonal
antibody that inhibits interleukin-8 (IL-8), a chemokine that promotes tumor progression …
antibody that inhibits interleukin-8 (IL-8), a chemokine that promotes tumor progression …
The role of neutrophil extracellular traps in cancer progression, metastasis and therapy
Y Chen, H Hu, S Tan, Q Dong, X Fan, Y Wang… - … Hematology & Oncology, 2022 - Springer
Neutrophil extracellular traps (NETs) released by activated neutrophils typically consist of
DNA-histone complexes and granule proteins. NETs were originally identified as a host …
DNA-histone complexes and granule proteins. NETs were originally identified as a host …
Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells
Breast cancer stem-like cells (CSCs) are an important therapeutic target as they are
purported to be responsible for tumor initiation, maintenance, metastases, and disease …
purported to be responsible for tumor initiation, maintenance, metastases, and disease …