A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor
The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …
prompted scientists to address an urgent need for defining mechanisms of disease …
Neprilysin is a mediator of alternative renin-angiotensin-system activation in the murine and human kidney
O Domenig, A Manzel, N Grobe, E Königshausen… - Scientific reports, 2016 - nature.com
Cardiovascular and renal pathologies are frequently associated with an activated renin-
angiotensin-system (RAS) and increased levels of its main effector and vasoconstrictor …
angiotensin-system (RAS) and increased levels of its main effector and vasoconstrictor …
Endothelial dysfunction in Sickle Cell Disease: Strategies for the treatment
AR Pavan, B Terroni, JL Dos Santos - Nitric Oxide, 2024 - Elsevier
Abstract Sickle Cell Anemia (SCA), is an inherited hemoglobinopathy characterized by the
presence of an abnormal hemoglobin (HbS), being the most prevalent sickle cell disease …
presence of an abnormal hemoglobin (HbS), being the most prevalent sickle cell disease …
Oleanolic acid modulates the renin-angiotensin system and cardiac natriuretic hormone concomitantly with volume and pressure balance in rats
YM Ahn, YH Choi, JJ Yoon, YJ Lee, KW Cho… - European journal of …, 2017 - Elsevier
Oleanolic acid is known to possess beneficial effects on the regulation of the cardiovascular
homeostasis. However, the exact nature of the role of oleanolic acid on the regulation of …
homeostasis. However, the exact nature of the role of oleanolic acid on the regulation of …
ATR1 angiotensin II receptor reduces hemoglobin s polymerization, phosphatidylserine exposure, and increases deformability of sickle cell disease erythrocytes
CC Guimarães-Nobre, E Mendonça-Reis… - Cell Biochemistry and …, 2022 - Springer
Abstract Angiotensin II (Ang II) regulates blood volume and stimulates erythropoiesis
through AT1 (ATR1) and AT2 (ATR2) receptors, found in multiple tissues, including …
through AT1 (ATR1) and AT2 (ATR2) receptors, found in multiple tissues, including …
Reduced blood pressure in sickle cell disease is associated with decreased angiotensin converting enzyme (ACE) activity and is not modulated by ACE inhibition
Background Sickle cell disease (SCD) incurs vaso-occlusive episodes and organ damage,
including nephropathy. Despite displaying characteristics of vascular dysfunction, SCD …
including nephropathy. Despite displaying characteristics of vascular dysfunction, SCD …
Low urinary levels of angiotensin‐converting enzyme 2 may contribute to albuminuria in children with sickle cell anaemia.
AR Belisário, ÉLM Vieira, JA Almeida… - British Journal of …, 2019 - search.ebscohost.com
The article discusses the clinical trials which have shown that angiotensin-converting
enzyme inhibitors (ACEi) can effectively reduce albuminuria in patients with sickle cell …
enzyme inhibitors (ACEi) can effectively reduce albuminuria in patients with sickle cell …
Vascular effects of the fetal hemoglobin inducer agent 3-(1, 3-dioxoisoindolin-2-yl) benzyl nitrate
B Terroni, LHO de Moraes, AR Pavan, GJ Rodrigues… - Pharmaceuticals, 2022 - mdpi.com
Vascular endothelium is a protective layer of cells lining the lumen of blood vessels that
plays important roles by releasing factors responsible for controlling the vascular tone …
plays important roles by releasing factors responsible for controlling the vascular tone …
[HTML][HTML] Hormones Action on Erythrocytes and Signaling Pathways
CC Guimarães-Nobre, E Mendonça-Reis… - The Erythrocyte-A …, 2023 - intechopen.com
Erythrocytes are the most abundant cell type in the human body, although considered as
merely hemoglobin carriers for a long time. Extensive studies on its biochemical pathways …
merely hemoglobin carriers for a long time. Extensive studies on its biochemical pathways …