Manganese (Mn) is an essential trace element that participates in various physiological and
pathological processes. However, epidemiological observations indicate that overexposure …

Despite the high prevalence of osteoarthritis (OA) in older populations, disease-modifying
OA drugs (DMOADs) are still lacking. This study was performed to investigate the effects and …

Diabetes is a widespread disease characterized by high blood glucose levels due to
abnormal insulin activity, production, or both. Chronic diabetes causes many secondary …

Protein aggregation is one of the major pathological events in age-related Parkinson's
disease (PD) pathology, predominantly regulated by the ubiquitin–proteasome system …

Background The excessive activation of the microglia leads to the release of inflammatory
factors that contribute to neuronal cell loss and neurodegeneration in Parkinson's Disease …

Acupuncture has demonstrated its efficacy as a treatment for Parkinson's disease (PD).
Thus, the objective of this study was to investigate the potential mechanisms underlying …

Objective To investigate the protective effects and its possible mechanism of Wuzi Yanzong
Pill (WYP) on Parkinson's disease (PD) model mice. Methods Thirty-six C57BL/6 male mice …

Parkinson's disease (PD) is the second most common neurodegenerative disorder in
worldwide and remains a therapeutic challenge due to the low efficacy of current treatments …

Alzheimer's (AD) and Parkinson's (PD) diseases are two distinct age-related pathologies
that are characterized by various common dysfunctions. They are referred to as …

Nicotinamide riboside (NR) is a precursor and exogenous supplement of nicotinamide
adenine dinucleotide (NAD+). NR has been shown to play a beneficial role in a variety of …