Recent medical advances have exploited the ability to address a given disease at the
underlying level of transcription and translation. These treatment paradigms utilize nucleic …

Post‐transcriptional gene silencing targets and degrades mRNA transcripts, silencing the
expression of specific genes. RNA interference technology, using synthetic structurally well …

The RNA interference (RNAi) pathway possesses immense potential in silencing any gene
in human cells. Small interfering RNA (siRNA) can efficiently trigger RNAi silencing of …

One of the most important advances in biology has been the discovery that siRNA (small
interfering RNA) is able to regulate the expression of genes, by a phenomenon known as …

In the 10 years that have passed since the Nobel prize-winning discovery of RNA
interference (RNAi), billions of dollars have been invested in the therapeutic application of …

Nanocarriers offer unique possibilities to overcome cellular barriers in order to improve the
delivery of various drugs and drug candidates, including the promising therapeutic …

Liposomes have been used extensively as micro-and nanocarriers for hydrophobic or
hydrophilic molecules. However, conventional liposomes are biodegradable and quickly …

RNA interference (RNAi) quietly crept into biological research in the 1990s when
unexpected gene-silencing phenomena in plants and flatworms first perplexed scientists …

The rapid identification of highly specific and potent drug candidates continues to be a
substantial challenge with traditional pharmaceutical approaches. Moreover, many targets …

With increasing knowledge on the molecular mechanisms of endogenous RNA interference,
small interfering RNAs (siRNAs) have been emerging as innovative nucleic acid medicines …