Fifty shades of brain: a review on the mechanical testing and modeling of brain tissue

S Budday, TC Ovaert, GA Holzapfel… - … Methods in Engineering, 2020 - Springer
Brain tissue is not only one of the most important but also the most complex and compliant
tissue in the human body. While long underestimated, increasing evidence confirms that …

Use of brain biomechanical models for monitoring impact exposure in contact sports

S Ji, M Ghajari, H Mao, RH Kraft… - Annals of Biomedical …, 2022 - Springer
Head acceleration measurement sensors are now widely deployed in the field to monitor
head kinematic exposure in contact sports. The wealth of impact kinematics data provides …

Six degree-of-freedom measurements of human mild traumatic brain injury

F Hernandez, LC Wu, MC Yip, K Laksari… - Annals of biomedical …, 2015 - Springer
This preliminary study investigated whether direct measurement of head rotation improves
prediction of mild traumatic brain injury (mTBI). Although many studies have implicated …

An anatomically detailed and personalizable head injury model: Significance of brain and white matter tract morphological variability on strain

X Li, Z Zhou, S Kleiven - Biomechanics and modeling in mechanobiology, 2021 - Springer
Finite element head (FE) models are important numerical tools to study head injuries and
develop protection systems. The generation of anatomically accurate and subject-specific …

Brain injury tolerance limit based on computation of axonal strain

D Sahoo, C Deck, R Willinger - Accident Analysis & Prevention, 2016 - Elsevier
Traumatic brain injury (TBI) is the leading cause of death and permanent impairment over
the last decades. In both the severe and mild TBIs, diffuse axonal injury (DAI) is the most …

Finite element methods in human head impact simulations: a review

A Madhukar, M Ostoja-Starzewski - Annals of biomedical engineering, 2019 - Springer
Head impacts leading to traumatic brain injury (TBI) present a major health risk today,
projected to become the third leading cause of death by 2020. While finite element (FE) …

Explicit modeling of white matter axonal fiber tracts in a finite element brain model

T Wu, A Alshareef, JS Giudice, MB Panzer - Annals of biomedical …, 2019 - Springer
Many human brain finite element (FE) models lack mesoscopic (~ 1 mm) white matter
structures, which may limit their capability in predicting TBI and assessing tissue-based …

Embedded axonal fiber tracts improve finite element model predictions of traumatic brain injury

M Hajiaghamemar, T Wu, MB Panzer… - … and modeling in …, 2020 - Springer
With the growing rate of traumatic brain injury (TBI), there is an increasing interest in
validated tools to predict and prevent brain injuries. Finite element models (FEM) are …

Boundary conditions investigation to improve computer simulation of cerebrospinal fluid dynamics in hydrocephalus patients

S Gholampour, N Fatouraee - Communications biology, 2021 - nature.com
Three-D head geometrical models of eight healthy subjects and 11 hydrocephalus patients
were built using their CINE phase-contrast MRI data and used for computer simulations …

Inverse identification of region-specific hyperelastic material parameters for human brain tissue

J Hinrichsen, N Reiter, L Bräuer, F Paulsen… - … and Modeling in …, 2023 - Springer
The identification of material parameters accurately describing the region-dependent
mechanical behavior of human brain tissue is crucial for computational models used to …