The panoply of cognitive, affective, motivational, and social functions that underpin everyday
human experience requires precisely choreographed patterns of interaction between …

A cornerstone for research into the link between stress and health has been the reactivity
hypothesis; cardiovascular reactivity to psychological stressors, if prolonged or exaggerated …

In this article, we propose integrated generalized structured component analysis (IGSCA),
which is a general statistical approach for analyzing data with both components and factors …

Structural equation modeling (SEM) is a versatile statistical method that should theoretically
be able to emulate all other methods that are based on the general linear model. In practice …

Drugs with similar side-effect profiles may share similar therapeutic properties through
related mechanisms of action. In this study, a drug-drug network was constructed based on …

Depression is a common and disabling psychiatric disorder with a complex etiology, which
includes predisposing risk genes and environmental stressors. Variation in the Catechol-O …

Behavioral activation is a fundamental feature of motivation, and organisms frequently make
effort-related decisions based upon evaluations of reinforcement value and response costs …

Children born very preterm are exposed to repeated neonatal procedures that induce pain
and stress during hospitalization in the neonatal intensive care unit (NICU). The COMT …

Dopamine and norepinephrine are key regulators of cognitive and affective processes. The
enzyme catechol-O-methyltransferase (COMT) catabolizes catecholamines and the COMT …

Both childhood trauma and a functional catechol-O-methyltransferase (COMT) genetic
polymorphism have been associated with posttraumatic stress disorder (PTSD) and …