Within the field of medical science, there is a great deal of interest in investigating cell death
pathways in the hopes of discovering new drugs. Over the past two decades …

Cardiovascular disease morbidity/mortality are increasing due to an aging population and
the rising prevalence of diabetes and obesity. Therefore, innovative cardioprotective …

Aims Regulated necrosis (necroptosis) and apoptosis are important biological features of
myocardial infarction, ischaemia-reperfusion (I/R) injury, and heart failure. However, the …

TRIM proteins are characterized by their conserved N-terminal RING, B-box, and coiled-coil
domains. These proteins are efficient regulators of autophagy, apoptosis, and innate …

Objective Primary graft dysfunction is often attributed to ischemia–reperfusion injury, and
prevention would be a therapeutic approach to mitigate injury. Mitsugumin 53, a myokine, is …

Abstract Background and Objective Our previous studies demonstrated that MG53 protein
can protect the myocardium, but its use as a therapeutic is challenging due to its short half …

Ischemia/reperfusion (I/R) injury is a common clinical problem after coronary angioplasty,
cardiopulmonary resuscitation, and organ transplantation, which can lead to cell damage …

Cardiomyopathies (CMs) are highly heterogeneous progressive heart diseases
characterised by structural and functional abnormalities of the heart, whose intricate …

Abstract Objective Ischemia/reperfusion (I/R) injury is an inevitable dilemma when
previously ischemic multiple organs and tissues are returned to a state of blood flow, with …

Additionally, DAMPs can initiate release of tumor necrosis factor-alpha (TNF-α), which when
bound to its receptors recruits cytosolic adaptor proteins to form complex I (which contains …