It is commonly accepted that the role of astrocytes exceeds far beyond neuronal scaffold and
energy supply. Their unique morphological and functional features have recently brough …

Abstract TGR5 (Gpbar‐1) is a membrane‐bound bile acid receptor in the gastrointestinal
tract and immune cells with pleiotropic actions. As shown in the present study, TGR5 is also …

Whilst astrocytes in culture invariably respond to dopamine with cytosolic Ca2+ rises, the
dopamine sensitivity of astroglia in situ and its physiological roles remain unknown. To …

Extracellular S100B dramatically increases after brain injury. While low S100B levels are
neuroprotective, micromolar S100B levels have shown in vitro to activate microglia and …

Astrocytes react to brain injury with a generic response known as reactive gliosis, which
involves activation of multiple intracellular pathways including several that may be beneficial …

Interleukin-1β (IL-1β) and the Ca 2+/calmodulin-dependent protein phosphatase,
calcineurin, have each been shown to play an important role in neuroinflammation …

Much progress has been made in understanding autoimmune channelopathies, but the
underlying pathogenic mechanisms are not always clear due to broad expression of some …

The effect of the natural essential oil thymol on cytosolic Ca2+ concentrations ([Ca2+] i) and
viability in human glioblastoma cells was examined. The Ca2+-sensitive fluorescent dye fura …

Astrocytes exhibit a complex, branched morphology, allowing them to functionally interact
with numerous blood vessels, neighboring glial processes and neuronal elements, including …

The lithium-pilocarpine model of epilepsy reproduces in rodents several features of human
temporal lobe epilepsy, by inducing an acute status epilepticus (SE) followed by a latency …