Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Protein kinases (PKs) have been recognized as central nervous system (CNS)-disease-
relevant targets due to their master regulatory role in different signal transduction cascades …

Abstract gem‐Heteroatom‐substituted fluoroalkenes have received little attention despite
their great potential in medicinal chemistry or in fine chemistry. Indeed, due to the electronic …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by
neuropathological deposits of amyloid plaques and neurofibrillary tangles comprised of β …

The comprehensive review contains the analysis of literature data concerning reactions of
heterocyclization of aminoazoles and demonstrates the application of these types of …

Protein kinases are key regulators of cellular signaling and play a critical role in
oncogenesis. Inhibitors of protein kinases are pursued by both industry and academia as a …

The exact etiology of Parkinson's disease (PD) remains obscure, although many cellular
mechanisms including α-synuclein aggregation, oxidative damage, excessive …

Uncontrolled cell proliferation is a hallmark of cancer as a result of rapid and deregulated
progression through the cell cycle. The inhibition of cyclin-dependent kinases (CDKs) …

It is known that 2-quinolones are broadly applicable chemical structures in medicinal and
agrochemical research as well as various functional materials. A number of current …

Sirtuin isoform 2 (SIRT2) is one of the seven sirtuin isoforms present in humans, being
classified as class III histone deacetylases (HDACs). Based on the high sequence similarity …