Osteoporosis is a common skeletal disease, affecting~ 200 million people around the world.
As a complex disease, osteoporosis is influenced by many factors, including diet (eg calcium …

Abstract TGF-β 1–3 are unique multi-functional growth factors that are only expressed in
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …

A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a
subject of recent interest, as its role in detoxifying aldehydes that accumulate through …

Osteoporosis is a major concern all over the world. With aging, a gradual loss of bone mass
results in osteopenia and osteoporosis. Heritable factors account for 60–80% of optimal …

Context: The primary goals of genome-wide association studies (GWAS) are to discover new
molecular and biological pathways involved in the regulation of bone metabolism that can …

Glucocorticoid (GC) exposure is the most common etiology of drug-induced (secondary)
osteoporosis. Twenty percent of all cases of osteoporosis have been attributed to GC …

Osteoporosis is a common age-related disorder characterized by low bone mass and
deterioration in bone microarchitecture, leading to increased skeletal fragility and fracture …

Purpose Traditional epidemiological studies suggest that there is an association between
age at menarche (years)(AAM) and bone mineral density (BMD) at the sites of the femoral …

Ethnopharmacological relevance Epimedium is a popular traditional herbal medicine
worldwide that has long been used to relieve osteoporosis. The estrogenic properties of the …

In the past few years, the bone field has witnessed great advances in genome-wide
association studies (GWASs) of osteoporosis, with a number of promising genes identified …