Twelve years of GWAS discoveries for osteoporosis and related traits: advances, challenges and applications
Osteoporosis is a common skeletal disease, affecting~ 200 million people around the world.
As a complex disease, osteoporosis is influenced by many factors, including diet (eg calcium …
As a complex disease, osteoporosis is influenced by many factors, including diet (eg calcium …
Transforming growth factor-β in stem cells and tissue homeostasis
Abstract TGF-β 1–3 are unique multi-functional growth factors that are only expressed in
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities
CH Chen, JCB Ferreira, ER Gross… - Physiological …, 2014 - journals.physiology.org
A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a
subject of recent interest, as its role in detoxifying aldehydes that accumulate through …
subject of recent interest, as its role in detoxifying aldehydes that accumulate through …
Medical treatment for osteoporosis: from molecular to clinical opinions
LR Chen, NY Ko, KH Chen - International journal of molecular sciences, 2019 - mdpi.com
Osteoporosis is a major concern all over the world. With aging, a gradual loss of bone mass
results in osteopenia and osteoporosis. Heritable factors account for 60–80% of optimal …
results in osteopenia and osteoporosis. Heritable factors account for 60–80% of optimal …
Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed
Context: The primary goals of genome-wide association studies (GWAS) are to discover new
molecular and biological pathways involved in the regulation of bone metabolism that can …
molecular and biological pathways involved in the regulation of bone metabolism that can …
Adverse effects of corticosteroids on bone metabolism: a review
R Mitra - PM&R, 2011 - Elsevier
Glucocorticoid (GC) exposure is the most common etiology of drug-induced (secondary)
osteoporosis. Twenty percent of all cases of osteoporosis have been attributed to GC …
osteoporosis. Twenty percent of all cases of osteoporosis have been attributed to GC …
Mesenchymal stem cells-derived exosomes: a possible therapeutic strategy for osteoporosis
Y Li, D Jin, W Xie, L Wen, W Chen, J Xu… - Current stem cell …, 2018 - ingentaconnect.com
Osteoporosis is a common age-related disorder characterized by low bone mass and
deterioration in bone microarchitecture, leading to increased skeletal fragility and fracture …
deterioration in bone microarchitecture, leading to increased skeletal fragility and fracture …
Age at menarche and osteoporosis: a Mendelian randomization study
Purpose Traditional epidemiological studies suggest that there is an association between
age at menarche (years)(AAM) and bone mineral density (BMD) at the sites of the femoral …
age at menarche (years)(AAM) and bone mineral density (BMD) at the sites of the femoral …
Anti-osteoporosis effect of Epimedium via an estrogen-like mechanism based on a system-level approach
F Xu, Y Ding, Y Guo, B Liu, Z Kou, W Xiao… - Journal of …, 2016 - Elsevier
Ethnopharmacological relevance Epimedium is a popular traditional herbal medicine
worldwide that has long been used to relieve osteoporosis. The estrogenic properties of the …
worldwide that has long been used to relieve osteoporosis. The estrogenic properties of the …
Genome-wide association studies for osteoporosis: a 2013 update
YJ Liu, L Zhang, CJ Papasian… - Journal of bone …, 2014 - synapse.koreamed.org
In the past few years, the bone field has witnessed great advances in genome-wide
association studies (GWASs) of osteoporosis, with a number of promising genes identified …
association studies (GWASs) of osteoporosis, with a number of promising genes identified …