Colorectal cancer (CRC) is the third most common cancer and the fourth most common
cause of cancer-related death worldwide. Besides the lymphatic and haematogenous routes …

Krüppel-associated box zinc finger proteins (KRAB-ZFPs) constitute the largest family of
transcriptional factors exerting co-repressor functions in mammalian cells. In general, KRAB …

Breast cancer cells frequently home to the bone marrow, where they may enter a dormant
state before forming a bone metastasis. Several members of the interleukin-6 (IL-6) cytokine …

Mutations in the TP53 gene and microenvironmentally driven activation of hypoxia-inducible
factor-1 (HIF-1) typically occur in later stages of tumorigenesis. An ongoing challenge is the …

Kruppel-associated box (KRAB) zinc-finger proteins (KRAB-ZFPs) are the largest
transcriptional/transcription-regulatory factor family in mammalian cells. The amino-terminal …

Growing evidence has demonstrated that epigenetic dysregulation is a common
pathological feature in human cancer cells. Global alterations in the epigenetic landscape …

Lung cancer is the most commonly diagnosed cancer worldwide and it is also the most
leading cause of cancer-related deaths. Although multiple generations of targeted …

Hypoxia is a feature of most solid tumours and predicts for poor prognosis. In radiobiological
hypoxia (< 0.1% O2) cells become up to three times more resistant to radiation. The …

Clinical applications of antiangiogenic agents profoundly affect tumor cell behaviors via the
resultant hypoxia. To date, how the hypoxia regulates tumor cells remains unclear. Here, we …

Urinary bladder cancer (UBC) is characterized by frequent recurrence and metastasis
despite the standard chemotherapy with gemcitabine and cisplatin combination. Histone …