Excitotoxicity is a phenomenon that describes the toxic actions of excitatory
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …

Abstract System xc− is a cystine/glutamate antiporter that exchanges extracellular cystine for
intracellular glutamate. Cystine is intracellularly reduced to cysteine, a building block of …

Acute myeloid leukemia (AML) is the most common type of acute leukemia and is a
heterogeneous clonal disorder. At present, the pathogenesis of AML and potential methods …

The cystine/glutamate antiporter or system exchanges cystine for glutamate, thereby
supporting intracellular glutathione synthesis and nonvesicular glutamate release. The role …

The importance of neuronal glutamate to synaptic transmission throughout the brain
illustrates the immense therapeutic potential and safety risks of targeting this system …

There is considerable preclinical and clinical evidence indicating that abnormal changes in
glutamatergic signaling underlie the development of mood disorders. Astrocytic glutamate …

Disruption of the glutamatergic homeostasis is commonly observed in neurological diseases
and has been frequently correlated with the altered expression and/or function of astrocytic …

Abstract xCT is the specific chain of the cystine/glutamate antiporter, which is widely
reported to support anti-oxidant defenses in vivo. xCT is therefore at the crossroads between …

Despite ample evidence for the therapeutic potential of inhibition of the cystine/glutamate
antiporter system xc− in neurological disorders and in cancer, none of the proposed …

Despite the lack of robust evidence of effectiveness, current treatment options for cancer-
induced depression (CID) are limited to those developed for non-cancer related depression …