Most animals reproduce sexually, but the genetic and molecular mechanisms that determine
the eventual sex of each embryo vary remarkably. DM domain genes, which are related to …

Arguably the most defining moment in our lives is fertilization, the point at which we inherit
either an X or a Y chromosome from our father. The profoundly different journeys of male …

The stem cell niches at the apex of Drosophila ovaries and testes have been viewed as
distinct in two major respects. While both contain germline stem cells, the testis niche also …

The Drosophila melanogaster sex hierarchy controls sexual differentiation of somatic cells
via the activities of the terminal genes in the hierarchy, doublesex (dsx) and fruitless (fru) …

The paucity of polymorphisms in single-copy genes on the Y chromosome of Drosophila
contrasts with data indicating that this chromosome has polymorphic phenotypic effects on …

The passage of an individual's genome to future generations is essential for the
maintenance of species and is mediated by highly specialized cells, the germ cells. Genetic …

Many adult stem cells divide asymmetrically to balance self-renewal and differentiation,
thereby maintaining tissue homeostasis. Asymmetric stem cell divisions depend on …

As the mammalian embryo develops, it must engage one of the two distinct programmes of
gene activity, morphogenesis and organogenesis that characterize males and females. In …

Cadherins are a group of membrane proteins responsible for cell adhesion. They are crucial
for cell sorting and recognition during the morphogenesis, but they also play many other …

Male-female differences in many developmental mechanisms lead to the formation of two
morphologically and physiologically distinct sexes. Although this is expected for traits with …