[HTML][HTML] Gender medicine: effects of sex and gender on cardiovascular disease manifestation and outcomes
V Regitz-Zagrosek, C Gebhard - Nature Reviews Cardiology, 2023 - nature.com
Despite a growing body of evidence, the distinct contributions of biological sex and the
sociocultural dimension of gender to the manifestations and outcomes of ischaemic heart …
sociocultural dimension of gender to the manifestations and outcomes of ischaemic heart …
Sex differences in energy metabolism: natural selection, mechanisms and consequences
F Mauvais-Jarvis - Nature Reviews Nephrology, 2024 - nature.com
Metabolic homeostasis operates differently in men and women. This sex asymmetry is the
result of evolutionary adaptations that enable women to resist loss of energy stores and …
result of evolutionary adaptations that enable women to resist loss of energy stores and …
[HTML][HTML] GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype
that we have previously shown to be highly efficient for discovery of genetic associations …
that we have previously shown to be highly efficient for discovery of genetic associations …
[HTML][HTML] Sex differences in brain protein expression and disease
Most complex human traits differ by sex, but we have limited insight into the underlying
mechanisms. Here, we investigated the influence of biological sex on protein expression …
mechanisms. Here, we investigated the influence of biological sex on protein expression …
[HTML][HTML] Whole-genome sequencing reveals host factors underlying critical COVID-19
A Kousathanas, E Pairo-Castineira, K Rawlik… - Nature, 2022 - nature.com
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic
variation influences the development of illness requiring critical care or hospitalization,–after …
variation influences the development of illness requiring critical care or hospitalization,–after …
Genome-wide association studies of cardiovascular disease
R Walsh, SJ Jurgens, J Erdmann… - Physiological …, 2023 - journals.physiology.org
Genome-wide association studies (GWAS) aim to identify common genetic variants that are
associated with traits and diseases. Since 2005, more than 5,000 GWAS have been …
associated with traits and diseases. Since 2005, more than 5,000 GWAS have been …
[HTML][HTML] Amplification is the primary mode of gene-by-sex interaction in complex human traits
Sex differences in complex traits are suspected to be in part due to widespread gene-by-sex
interactions (GxSex), but empirical evidence has been elusive. Here, we infer the mixture of …
interactions (GxSex), but empirical evidence has been elusive. Here, we infer the mixture of …
[HTML][HTML] Deciphering genetic causes for sex differences in human health through drug metabolism and transporter genes
Sex differences have been widely observed in human health. However, little is known about
the underlying mechanism behind these observed sex differences. We hypothesize that sex …
the underlying mechanism behind these observed sex differences. We hypothesize that sex …
Socio-cultural practices may have affected sex differences in stature in Early Neolithic Europe
SL Cox, N Nicklisch, M Francken, J Wahl… - Nature Human …, 2024 - nature.com
The rules and structure of human culture impact health as much as genetics or environment.
To study these relationships, we combine ancient DNA (n= 230), skeletal metrics (n= 391) …
To study these relationships, we combine ancient DNA (n= 230), skeletal metrics (n= 391) …
Quality control and analytic best practices for testing genetic models of sex differences in large populations
Phenotypic sex-based differences exist for many complex traits. In other cases, phenotypes
may be similar, but underlying biology may vary. Thus, sex-aware genetic analyses are …
may be similar, but underlying biology may vary. Thus, sex-aware genetic analyses are …