Genetics and genetic biomarkers in sporadic colorectal cancer
JM Carethers, BH Jung - Gastroenterology, 2015 - Elsevier
Sporadic colorectal cancer (CRC) is a somatic genetic disease in which pathogenesis is
influenced by the local colonic environment and the patient's genetic background …
influenced by the local colonic environment and the patient's genetic background …
[HTML][HTML] Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer
P Nowak-Sliwinska, L Scapozza, AR i Altaba - Biochimica et Biophysica …, 2019 - Elsevier
The strategy of using existing drugs originally developed for one disease to treat other
indications has found success across medical fields. Such drug repurposing promises faster …
indications has found success across medical fields. Such drug repurposing promises faster …
Discovery of common and rare genetic risk variants for colorectal cancer
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …
Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study
Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …
Determining risk of colorectal cancer and starting age of screening based on lifestyle, environmental, and genetic factors
J Jeon, M Du, RE Schoen, M Hoffmeister, PA Newcomb… - Gastroenterology, 2018 - Elsevier
Background & Aims Guidelines for initiating colorectal cancer (CRC) screening are based
on family history but do not consider lifestyle, environmental, or genetic risk factors. We …
on family history but do not consider lifestyle, environmental, or genetic risk factors. We …
Novel common genetic susceptibility loci for colorectal cancer
Background Previous genome-wide association studies (GWAS) have identified 42 loci (P<
5× 10− 8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts …
5× 10− 8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts …
Large-scale genome-wide association study of East Asians identifies loci associated with risk for colorectal cancer
Background & Aims Genome-wide association studies (GWASs) have associated
approximately 50 loci with risk of colorectal cancer (CRC)—nearly one third of these loci …
approximately 50 loci with risk of colorectal cancer (CRC)—nearly one third of these loci …
Genetic architecture of colorectal cancer
U Peters, S Bien, N Zubair - Gut, 2015 - gut.bmj.com
Colorectal cancer (CRC) is a complex disease that develops as a consequence of both
genetic and environmental risk factors. A small proportion (3–5%) of cases arise from …
genetic and environmental risk factors. A small proportion (3–5%) of cases arise from …
Biological role of unsaturated fatty acid desaturases in health and disease
A Czumaj, T Śledziński - Nutrients, 2020 - mdpi.com
Polyunsaturated fatty acids (PUFAs) are considered one of the most important components
of cells that influence normal development and function of many organisms, both eukaryotes …
of cells that influence normal development and function of many organisms, both eukaryotes …
Genome-wide association study of colorectal cancer identifies six new susceptibility loci
Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and
common genetic variants that contribute to familial risk. Here we report the results of a two …
common genetic variants that contribute to familial risk. Here we report the results of a two …