ATP-binding cassette (ABC) transporters are involved in active pumping of many diverse
substrates through the cellular membrane. The transport mediated by these proteins …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms and a large number of specific transporters have evolved to carry out this …

ABCA1, an ATP-binding cassette (ABC) subfamily A exporter, mediates the cellular efflux of
phospholipids and cholesterol to the extracellular acceptor apolipoprotein AI (apoA-I) for …

This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

The metabolism of high-density lipoproteins (HDL), which are inversely related to risk of
atherosclerotic cardiovascular disease, involves a complex interplay of factors regulating …

Tangier disease, a condition characterized by low levels of high density lipoprotein and
cholesterol accumulation in macrophages, is caused by mutations in the ATP-binding …

▪ Abstract The metabolic nuclear receptors act as metabolic and toxicological sensors,
enabling the organism to quickly adapt to environmental changes by inducing the …

It is widely believed that HDL functions to transport cholesterol from peripheral cells to the
liver by reverse cholesterol transport, a pathway that may protect against atherosclerosis by …

The concentration, composition, shape, and size of plasma high-density lipoprotein (HDL)
are determined by numerous proteins that influence its biogenesis, remodeling, and …