Abstract The RNA World Hypothesis suggests that prebiotic life revolved around RNA
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …

Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

Centromeric integrity is key for proper chromosome segregation during cell division.
Centromeres have unique chromatin features that are essential for centromere …

Satellite DNA represents one of the most fascinating parts of the repetitive fraction of the
eukaryotic genome. Since the discovery of highly repetitive tandem DNA in the 1960s, a lot …

The centromere is the region of the chromosome that directs its segregation in mitosis and
meiosis. Although the functional importance of the centromere has been appreciated for …

For the last four decades, we have known that noncoding RNAs maintain critical
housekeeping functions such as transcription, RNA processing, and translation. However, in …

Although it was nearly 70 years ago when transposable elements (TEs) were first
discovered “jumping” from one genomic location to another, TEs are now recognized as …

Human centromeres are defined by alpha satellite DNA arrays that are distinct and
chromosome specific. Most human chromosomes contain multiple alpha satellite arrays that …

Satellite DNAs are now regarded as powerful and active contributors to genomic and
chromosomal evolution. Paired with mobile transposable elements, these repetitive …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …