Eukayotic protein kinases evolved as a family of highly dynamic molecules with strictly
organized internal architecture. A single hydrophobic F-helix serves as a central scaffold for …

Protein kinases have very dynamic structures and their functionality strongly depends on
their dynamic state. Active kinases reveal a dynamic pattern with residues clustering into …

Protein kinases are dynamically regulated signaling proteins that act as switches in the cell
by phosphorylating target proteins. To establish a framework for analyzing linkages between …

Enzymes control chemical reactions that are key to life processes, and allow them to take
place on the time scale needed for synchronization between the relevant reaction cycles. In …

Conspectus Protein function is inextricably linked to protein dynamics. As we move from a
static structural picture to a dynamic ensemble view of protein structure and function, novel …

The first protein kinase structure, solved in 1991, revealed the fold that is shared by all
members of the eukaryotic protein kinase superfamily and showed how the conserved …

The calcium pump (aka Ca 2+-ATPase or SERCA) is a membrane transport protein
ubiquitously found in the endoplasmic reticulum (ER) of all eukaryotic cells. As a calcium …

The mutation and overexpression of the epidermal growth factor receptor (EGFR) are
associated with the development of a variety of cancers, making this prototypical …

It is well-established that dynamics are central to protein function; their importance is
implicitly acknowledged in the principles of the Monod, Wyman and Changeux model of …

Protein kinases have evolved in eukaryotes to be highly dynamic molecular switches that
regulate a plethora of biological processes. Two motifs, a dynamic activation segment and a …