Fractionated radiotherapy after gross total resection of clival chordoma: a systematic review of survival outcomes

JL Gendreau, NUF Hameed, A Jimenez… - …, 2023 - journals.lww.com
BACKGROUND: Current treatment guidelines for clival chordomas recommend surgical
resection followed by high-dose radiotherapy (RT). However, in patients in whom gross total …

Chordoma: Genetics and Contemporary Management

R Desai, PE Pelargos, IF Dunn - International Journal of Molecular …, 2024 - mdpi.com
Chordomas, arising from notochord remnants, are rare neoplasms with aggressive growth
patterns despite their histologically low-grade nature. This review explores their …

Comparison of tumor control after stereotactic radiosurgery or pencil beam proton therapy for newly diagnosed clival chordomas: a single-center retrospective study

S Hong, A Mahajan, NN Laack, MJ Link, Y Shinya… - World neurosurgery, 2023 - Elsevier
Objective To compare outcomes of proton radiation therapy (PRT), stereotactic radiosurgery
(SRS), and x-ray-based radiation with an SRS boost (XRT+ SRS) for newly diagnosed clival …

Longitudinal treatment outcomes of recurrent clival chordomas: a single-center retrospective study

S Hong, A Mahajan, Y Shinya, NN Laack, MJ Link… - Journal of …, 2023 - thejns.org
OBJECTIVE The objective of this study was to clarify the detailed clinical course of recurrent
clival chordoma and the outcomes of each treatment modality. METHODS A single-center …

Fractionated radiotherapy after gross-total resection of spinal chordoma: a systematic review of survival outcomes using individualized patient data

JL Gendreau, K Gowda, F Kazemi, M Horowitz… - … of Neurosurgery: Spine, 2024 - thejns.org
OBJECTIVE Spinal chordoma treatment guidelines recommend resection. However, in
patients in whom gross-total resection (GTR) is achieved, the benefits of radiation therapy …

Long-term outcome of primary clival chordomas: a single-center retrospective study with an emphasis on the timing of recurrences based on the primary treatment

S Hong, Y Shinya, A Mahajan, NN Laack… - Neurosurgical …, 2024 - thejns.org
OBJECTIVE This study aimed to provide data on extended outcomes in primary clival
chordomas, focusing on progression-free survival (PFS) and overall survival (OS) …

Supramarginal resection of skull base chordomas: proof of concept and preliminary outcomes

J Rychen, F Constanzo, Y Xu, TM Johnstone, A Bex… - Neurosurgical …, 2024 - thejns.org
OBJECTIVE The mainstay of treatment for skull base chordoma (SBC) is maximal safe
resection followed by radiotherapy. However, even after gross-total resection (GTR), the …

The mFI-5 and Postoperative Outcomes in Brain Tumor Patients: A Bayesian Approach to Quantifying Uncertainty

AE Jimenez, JL Porras, TD Azad, AS Luksik… - World neurosurgery, 2023 - Elsevier
Objective To the best of our knowledge, prior research has not investigated the uncertainty
in the relationship between patient frailty and postoperative outcomes after brain tumor …