WNKs are serine/threonine kinases that comprise a unique branch of the kinome. They are
so-named owing to the unusual placement of an essential catalytic lysine. WNKs have now …

The p75 neurotrophin receptor (p75 NTR) functions at the molecular nexus of cell death,
survival, and differentiation. In addition to its contribution to neurodegenerative diseases and …

In the adult mammalian CNS, chondroitin sulfate proteoglycans (CSPGs) and myelin-
associated inhibitors (MAIs) stabilize neuronal structure and restrict compensatory sprouting …

Multiple lines of evidence have validated the Rho pathway as important in controlling the
neuronal response to growth inhibitory proteins after central nervous system (CNS) injury. A …

Growing clinical, neuro-imaging and post-mortem data have implicated the cerebellum as
playing an important role in the pathogenesis of essential tremor. Aside from a modest …

Current therapies have limited capacity to curtail disease progression or damage of the
central nervous system (CNS) of adult mammals and successful regeneration following …

The nerve growth factor (NGF) belongs to the neurotrophin family and induces its effects
through activation of 2 distinct receptor types: the tropomyosin-related kinase A (TrkA) …

Aged individuals exhibit reduced functional recovery after stroke. We examined the
expression profile in aged animals of a recently identified group of growth-associated genes …

Abstract The sigma-1 receptor (Sig-1R) is a single 25 kD polypeptide and a chaperone
protein immersed in lipid rafts of the endoplasmic reticulum (ER) where it interacts with …

Injury to axons elicits changes in macromolecule synthesis in the corresponding cell bodies
that are critical for an effective regenerative response. For decades the most easily studied …