Synthetic biology and computer-based frameworks for antimicrobial peptide discovery

MDT Torres, J Cao, OL Franco, TK Lu… - ACS …, 2021 - ACS Publications
Antibiotic resistance is one of the greatest challenges of our time. This global health problem
originated from a paucity of truly effective antibiotic classes and an increased incidence of …

Probiotic engineering strategies for the heterologous production of antimicrobial peptides

A Mejía-Pitta, E Broset, C de la Fuente-Nunez - Advanced drug delivery …, 2021 - Elsevier
Engineered probiotic bacteria represent an innovative approach for treating and detecting a
wide range of diseases including those caused by infectious agents. Antimicrobial peptides …

Photoelectric Bacteria Enhance the In Situ Production of Tetrodotoxin for Antitumor Therapy

XN Wang, MT Niu, JX Fan, QW Chen, XZ Zhang - Nano Letters, 2021 - ACS Publications
Engineered bacteria are promising bioagents to synthesize antitumor drugs at tumor sites
with the advantages of avoiding drug leakage and degradation during delivery. Here, we …

Generation of multivalent nanobody-based proteins with improved neutralization of long α-neurotoxins from elapid snakes

J Wade, C Rimbault, H Ali, L Ledsgaard… - Bioconjugate …, 2022 - ACS Publications
Recombinantly produced biotherapeutics hold promise for improving the current standard of
care for snakebite envenoming over conventional serotherapy. Nanobodies have performed …

Reprogramming biological peptides to combat infectious diseases

MDT Torres, C de la Fuente-Nunez - Chemical Communications, 2019 - pubs.rsc.org
With the rapid spread of resistance among parasites and bacterial pathogens, antibiotic-
resistant infections have drawn much attention worldwide. Consequently, there is an urgent …

Non-mammalian eukaryotic expression systems yeast and fungi in the production of biologics

M Garvey - Journal of Fungi, 2022 - mdpi.com
Biologics have become an important area of medical research generating therapeutics
essential for the treatment of many disease states. Biologics are defined as biologically …

Engineered living materials based on adhesin-mediated trapping of programmable cells

S Guo, E Dubuc, Y Rave, M Verhagen… - ACS synthetic …, 2020 - ACS Publications
Engineered living materials have the potential for wide-ranging applications such as
biosensing and treatment of diseases. Programmable cells provide the functional basis for …

Genetic engineering approaches to improve posttranslational modification of biopharmaceuticals in different production platforms

T Amann, V Schmieder… - Biotechnology and …, 2019 - Wiley Online Library
The number of approved biopharmaceuticals, where product quality attributes remain of
major importance, is increasing steadily. Within the available variety of expression hosts, the …

Applications of yeast synthetic biology geared towards the production of biopharmaceuticals

RSK Walker, IS Pretorius - Genes, 2018 - mdpi.com
Engineered yeast are an important production platform for the biosynthesis of high-value
compounds with medical applications. Recent years have witnessed several new …

Process and operations strategies to enable global access to antibody therapies

B Kelley, T Renshaw, M Kamarck - Biotechnology Progress, 2021 - Wiley Online Library
Few monoclonal antibodies are currently approved for treating infectious diseases, but
multiple products are in development against a broad range of infectious diseases, including …