Extracellular miRNAs: from biomarkers to mediators of physiology and disease
miRNAs can be found in serum and other body fluids and serve as biomarkers for disease.
More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as …
More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as …
Therapeutic targeting of long non-coding RNAs in cancer
Long non-coding RNAs (lncRNAs) represent a significant population of the human
transcriptome. Many lncRNAs exhibit cell-and/or tissue/tumor-specific expression, making …
transcriptome. Many lncRNAs exhibit cell-and/or tissue/tumor-specific expression, making …
Interplay between miRNAs and human diseases
P Paul, A Chakraborty, D Sarkar… - Journal of cellular …, 2018 - Wiley Online Library
MicroRNAs (miRNAs) are endogenous, non‐coding RNAs, which have evoked a great deal
of interest due to their importance in many aspects of homeostasis and diseases …
of interest due to their importance in many aspects of homeostasis and diseases …
Therapeutic targeting of microRNAs: current status and future challenges
Z Li, TM Rana - Nature reviews Drug discovery, 2014 - nature.com
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that have crucial
roles in regulating gene expression. Increasing evidence supports a role for miRNAs in …
roles in regulating gene expression. Increasing evidence supports a role for miRNAs in …
Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish
The widespread availability of programmable site-specific nucleases now enables targeted
gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate …
gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate …
MicroRNAs in metabolism and metabolic disorders
V Rottiers, AM Näär - Nature reviews Molecular cell biology, 2012 - nature.com
MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example,
miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in …
miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in …
Development of micro RNA therapeutics is coming of age
E Van Rooij, S Kauppinen - EMBO molecular medicine, 2014 - embopress.org
Micro RNA s (mi RNA s) play key regulatory roles in diverse biological processes and are
frequently dysregulated in human diseases. Thus, mi RNA s have emerged as a class of …
frequently dysregulated in human diseases. Thus, mi RNA s have emerged as a class of …
Targeting long non-coding RNAs in cancers: progress and prospects
CH Li, Y Chen - The international journal of biochemistry & cell biology, 2013 - Elsevier
Pervasive transcription occurs in the human genome to generate thousands of RNA
transcripts, and accumulating evidence suggested that the RNA molecules, without protein …
transcripts, and accumulating evidence suggested that the RNA molecules, without protein …
Anti-miRNA oligonucleotides: A comprehensive guide for design
MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression
post-transcriptionally. As a consequence of their function towards mRNA, miRNAs are …
post-transcriptionally. As a consequence of their function towards mRNA, miRNAs are …
Inhibition of microRNA function by antimiR oligonucleotides
MicroRNAs (miRNAs) have emerged as important post-transcriptional regulators of gene
expression in many developmental and cellular processes. Moreover, there is now ample …
expression in many developmental and cellular processes. Moreover, there is now ample …