Extracellular miRNAs: from biomarkers to mediators of physiology and disease

MA Mori, RG Ludwig, R Garcia-Martin, BB Brandão… - Cell metabolism, 2019 - cell.com
miRNAs can be found in serum and other body fluids and serve as biomarkers for disease.
More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as …

Therapeutic targeting of long non-coding RNAs in cancer

G Arun, SD Diermeier, DL Spector - Trends in molecular medicine, 2018 - cell.com
Long non-coding RNAs (lncRNAs) represent a significant population of the human
transcriptome. Many lncRNAs exhibit cell-and/or tissue/tumor-specific expression, making …

Interplay between miRNAs and human diseases

P Paul, A Chakraborty, D Sarkar… - Journal of cellular …, 2018 - Wiley Online Library
MicroRNAs (miRNAs) are endogenous, non‐coding RNAs, which have evoked a great deal
of interest due to their importance in many aspects of homeostasis and diseases …

Therapeutic targeting of microRNAs: current status and future challenges

Z Li, TM Rana - Nature reviews Drug discovery, 2014 - nature.com
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that have crucial
roles in regulating gene expression. Increasing evidence supports a role for miRNAs in …

Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish

FO Kok, M Shin, CW Ni, A Gupta, AS Grosse… - Developmental cell, 2015 - cell.com
The widespread availability of programmable site-specific nucleases now enables targeted
gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate …

MicroRNAs in metabolism and metabolic disorders

V Rottiers, AM Näär - Nature reviews Molecular cell biology, 2012 - nature.com
MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example,
miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in …

Development of micro RNA therapeutics is coming of age

E Van Rooij, S Kauppinen - EMBO molecular medicine, 2014 - embopress.org
Micro RNA s (mi RNA s) play key regulatory roles in diverse biological processes and are
frequently dysregulated in human diseases. Thus, mi RNA s have emerged as a class of …

Targeting long non-coding RNAs in cancers: progress and prospects

CH Li, Y Chen - The international journal of biochemistry & cell biology, 2013 - Elsevier
Pervasive transcription occurs in the human genome to generate thousands of RNA
transcripts, and accumulating evidence suggested that the RNA molecules, without protein …

Anti-miRNA oligonucleotides: A comprehensive guide for design

JF Lima, L Cerqueira, C Figueiredo, C Oliveira… - RNA biology, 2018 - Taylor & Francis
MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression
post-transcriptionally. As a consequence of their function towards mRNA, miRNAs are …

Inhibition of microRNA function by antimiR oligonucleotides

J Stenvang, A Petri, M Lindow, S Obad, S Kauppinen - Silence, 2012 - Springer
MicroRNAs (miRNAs) have emerged as important post-transcriptional regulators of gene
expression in many developmental and cellular processes. Moreover, there is now ample …