Lipid‐based nanoparticles have emerged as a clinically viable platform technology to
deliver nucleic acids for a wide range of healthcare applications. Within this scope, one of …

One of the most significant paradigm shifts in membrane remodeling is the emerging view
that membrane transformation is not exclusively controlled by cytoskeletal rearrangement …

Nucleic acids, such as messenger RNAs, antisense oligonucleotides, and short interfering
RNAs, hold great promise for treating previously 'undruggable'diseases. However, there are …

In this study, we report lubrication properties of physisorbed zwitterionic bottlebrush
polymers in the presence of multivalent ions using the surface force apparatus. Unlike …

Evidence from post-mortem, genetic, neuroimaging, and non-human animal research
suggests that Major Depressive Disorder (MDD) is associated with abnormalities in brain …

The classic isoforms of myelin basic protein (MBP, 14–21.5 kDa) are essential to formation
of the multilamellar myelin sheath of the mammalian central nervous system (CNS). The …

Myelination occurs selectively around neuronal axons to increase the efficiency and velocity
of action potentials. While oligodendrocytes are capable of myelinating permissive …

Low molecular weight chitosan (LMW chitosan,∼ 5 kDa) potentially has many desirable
biomedical applications such as anti-microbial, anti-tumor, and anti-diabetes. Unlike high …

Oligodendrocytes are the glial cells responsible for the formation of the myelin sheath
around axons. During neurodevelopment, oligodendrocytes undergo maturation and …

Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the
basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm …